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Cdk8 cyclin-dependent kinase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498140, updated on 27-Nov-2024

Summary

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Official Symbol
Cdk8provided by RGD
Official Full Name
cyclin-dependent kinase 8provided by RGD
Primary source
RGD:1560888
See related
EnsemblRapid:ENSRNOG00000039819 AllianceGenome:RGD:1560888
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560888
Summary
Contributes to ubiquitin protein ligase activity. Involved in negative regulation of triglyceride metabolic process and protein ubiquitination. Part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 121.4), Kidney (RPKM 108.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdk8 in Genome Data Viewer
Location:
12p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13851024..13919017, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8737198..8805026, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10496273..10561335, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29-like Neighboring gene WASP family member 3 Neighboring gene uncharacterized LOC120095890 Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene uncharacterized LOC120095930 Neighboring gene ring finger protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Association between CDK8 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population. Zhang R, et al. Cardiovasc Diagn Ther, 2021 Oct. PMID 34815954, Free PMC Article
  2. MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8. Dou P, et al. J Biosci, 2021. PMID 33737500
  3. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Porter DC, et al. Proc Natl Acad Sci U S A, 2012 Aug 21. PMID 22869755, Free PMC Article
  4. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, et al. Chem Rev, 2013 Nov 13. PMID 23837720
  5. Updating the RNA polymerase CTD code: adding gene-specific layers. Egloff S, et al. Trends Genet, 2012 Jul. PMID 22622228

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8.
    Title: MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CKM complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 8
NP_001102531.1
XP_038945612.1
XP_038945613.1
XP_038945614.1
XP_038945615.1
XP_038945616.1
XP_038945618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109061.1 → NP_001102531.1  cyclin-dependent kinase 8

    See identical proteins and their annotated locations for NP_001102531.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474012
    UniProtKB/TrEMBL
    A0A8I5ZYM4, A6K1D1
    Related
    ENSRNOP00000081852.2, ENSRNOT00000092276.3
    Conserved Domains (1) summary
    cd07868
    Location:3 → 335
    STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    13851024..13919017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089687.2 → XP_038945615.1  cyclin-dependent kinase 8 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVW8, A0A8I5ZYM4
    Conserved Domains (1) summary
    cl21453
    Location:3 → 287
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039089686.2 → XP_038945614.1  cyclin-dependent kinase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZYM4
    Conserved Domains (1) summary
    cl21453
    Location:3 → 325
    PKc_like; Protein Kinases, catalytic domain

  3. XM_039089685.2 → XP_038945613.1  cyclin-dependent kinase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYM4
    Conserved Domains (1) summary
    cl21453
    Location:3 → 330
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039089684.2 → XP_038945612.1  cyclin-dependent kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYM4
    Conserved Domains (1) summary
    cd07868
    Location:3 → 335
    STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

  5. XM_039089688.2 → XP_038945616.1  cyclin-dependent kinase 8 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZYM4
    Conserved Domains (1) summary
    cl21453
    Location:1 → 275
    PKc_like; Protein Kinases, catalytic domain

  6. XM_039089690.2 → XP_038945618.1  cyclin-dependent kinase 8 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:3 → 228
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_010056410.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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