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Sh3bgr SH3 domain binding glutamate-rich protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 498066, updated on 4-Jan-2025

Summary

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Symbol
Sh3bgrprovided by RGD
Full Name
SH3 domain binding glutamate-rich proteinprovided by RGD
Primary source
RGD:1563599
See related
EnsemblRapid:ENSRNOG00000028238 AllianceGenome:RGD:1563599
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563599
Summary
Predicted to be active in cytoplasm. Orthologous to human SH3BGR (SH3 domain binding glutamate rich protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 2469.7) and Heart (RPKM 1235.5) See more
Orthologs
human mouse all
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Genomic context

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See Sh3bgr in Genome Data Viewer
Location:
11q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48973033..48997328)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (35503663..35527853)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (36555354..36579537)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene guided entry of tail-anchored proteins factor 1 Neighboring gene lebercilin LCA5 like Neighboring gene Beta-1,3-galactosyltransferase 5 Neighboring gene microRNA 6325

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH3 domain-binding glutamic acid-rich protein
Names
SH3 domain-binding glutamic acid-rich protein-like
SH3-binding domain glutamic acid-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127682.1 → NP_001121154.1  SH3 domain-binding glutamic acid-rich protein

    See identical proteins and their annotated locations for NP_001121154.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474083
    UniProtKB/TrEMBL
    A6KPR6, D3ZU20
    Related
    ENSRNOP00000063900.1, ENSRNOT00000064981.5
    Conserved Domains (1) summary
    pfam04908
    Location:1 → 98
    SH3BGR; SH3-binding, glutamic acid-rich protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    48973033..48997328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248184.3 → XP_006248246.1  SH3 domain-binding glutamic acid-rich protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZ80
    Conserved Domains (1) summary
    pfam04908
    Location:1 → 98
    SH3BGR; SH3-binding, glutamic acid-rich protein

  2. XM_063270698.1 → XP_063126768.1  SH3 domain-binding glutamic acid-rich protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZ80

  3. XM_039088575.2 → XP_038944503.1  SH3 domain-binding glutamic acid-rich protein isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZ80
    Conserved Domains (1) summary
    cd03030
    Location:2 → 77
    GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

  4. XM_039088574.2 → XP_038944502.1  SH3 domain-binding glutamic acid-rich protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZ80
    Related
    ENSRNOP00000084404.1, ENSRNOT00000119421.2
    Conserved Domains (1) summary
    cl00388
    Location:14 → 97
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  5. XM_063270699.1 → XP_063126769.1  SH3 domain-binding glutamic acid-rich protein isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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Chemical Information
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