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Spn42Da Serpin 42Da [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49805, updated on 4-Jan-2025

Summary

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Official Symbol
Spn42Daprovided by FlyBase
Official Full Name
Serpin 42Daprovided by FlyBase
Primary source
FLYBASE:FBgn0265137
Locus tag
Dmel_CG9453
See related
AllianceGenome:FB:FBgn0265137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9453; Dmel\CG9453; dSerp2; Serp2; sp4; Sp4; spn4; Spn4; Spn4A
Summary
Enables cysteine-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Involved in negative regulation of peptide hormone processing. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; dorsal ectoderm; epithelium; and gut section. Human ortholog(s) of this gene implicated in Alzheimer's disease and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to several human genes including SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Spn42Da in Genome Data Viewer
Location:
42D6-42D6; 2-55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6875906..6878927, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2763411..2766432, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Coronin Neighboring gene antisense RNA:CR44169 Neighboring gene uncharacterized protein Neighboring gene Serpin 42Db Neighboring gene Serpin 42Dc Neighboring gene Serpin 42Dd

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Widespread occurrence of serpin genes with multiple reactive centre-containing exon cassettes in insects and nematodes. Krüger O, et al. Gene, 2002 Jun 26. PMID 12137947
  2. Inhibition of furin by serpin Spn4A from Drosophila melanogaster. Oley M, et al. FEBS Lett, 2004 Nov 5. PMID 15527779
  3. Functional diversification of a protease inhibitor gene in the genus Drosophila and its molecular basis. Börner S, et al. Gene, 2008 May 31. PMID 18395367
  4. High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster. Ellisdon AM, et al. BMC Struct Biol, 2014 Apr 24. PMID 24758516, Free PMC Article
  5. Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases. Sfaxi F, et al. Oncotarget, 2014 Jun 30. PMID 24961901, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High resolution structure confirm for the first time that the Serpin 42 Da isoforms are typical inhibitory serpin family members with the conserved serpin fold and inhibitory mechanism.
    Title: High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.
  2. involved in the cellular regulation of prohormone convertases
    Title: Drosophila serpin 4 functions as a neuroserpin-like inhibitor of subtilisin-like proprotein convertases.
  3. Spn4 gene represents a versatile defence tool kit that may provide multiple antiproteolytic functions.
    Title: The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families.
  4. Results report the identification of Spn4A, a previously uncharacterized secretory pathway serine protease inhibitor (serpin) from Drosophila melanogaster that contains a consensus furin cleavage site.
    Title: The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of peptide hormone processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serpin 42Da
Names
CG9453-PA
CG9453-PB
CG9453-PD
CG9453-PE
CG9453-PF
CG9453-PG
CG9453-PH
CG9453-PI
CG9453-PJ
CG9453-PK
CG9453-PL
Serp2
Spn42Da-PA
Spn42Da-PB
Spn42Da-PD
Spn42Da-PE
Spn42Da-PF
Spn42Da-PG
Spn42Da-PH
Spn42Da-PI
Spn42Da-PJ
Spn42Da-PK
Spn42Da-PL
neuroserpin
serine protease inhibitor 4
serpin 4
serpin 42 Da

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6875906..6878927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206034.2 → NP_995756.1  serpin 42Da, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN7, Q8T0M5, Q9V991
    Conserved Domains (1) summary
    cd00172
    Location:45 → 404
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_206033.2 → NP_995755.1  serpin 42Da, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995755.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN5, Q9U1I5
    Conserved Domains (1) summary
    cd00172
    Location:13 → 372
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  3. NM_206039.3 → NP_995761.1  serpin 42Da, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995761.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN8, Q8T0M5, Q9V991
    Conserved Domains (1) summary
    cd00172
    Location:45 → 408
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  4. NM_206037.3 → NP_995759.1  serpin 42Da, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995759.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MM49, Q8T0M5, Q9V991
    Conserved Domains (1) summary
    cd00172
    Location:45 → 408
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  5. NM_206038.3 → NP_995760.1  serpin 42Da, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995760.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MM49, Q8T0M5, Q9V991
    Conserved Domains (1) summary
    cd00172
    Location:45 → 408
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  6. NM_165495.4 → NP_724511.2  serpin 42Da, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724511.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MM39, Q8T0M5, Q9V991
    Conserved Domains (1) summary
    cd00172
    Location:13 → 376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  7. NM_206036.2 → NP_995758.1  serpin 42Da, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995758.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN6, Q9U1I5
    Conserved Domains (1) summary
    cd00172
    Location:13 → 376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  8. NM_206032.2 → NP_995754.1  serpin 42Da, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995754.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MM39, Q8T0M5, Q9V991
    Conserved Domains (1) summary
    cd00172
    Location:13 → 376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  9. NM_206035.2 → NP_995757.1  serpin 42Da, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995757.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MM39, Q8T0M5, Q9V991
    Conserved Domains (1) summary
    cd00172
    Location:13 → 376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  10. NM_080216.3 → NP_524955.2  serpin 42Da, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524955.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K8Y5, Q9U1I5
    Related
    FBpp0085523
    Conserved Domains (1) summary
    cd00172
    Location:45 → 408
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  11. NM_165496.3 → NP_724512.1  serpin 42Da, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724512.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K8Y3, Q9U1I5
    Related
    FBpp0085524
    Conserved Domains (1) summary
    cd00172
    Location:13 → 376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K8Y3 Q7K8Y3
Q7K8Y5 Q7K8Y5
Q8MM39 Q8MM39
Q8MM49 Q8MM49
Q8MPN5 Q8MPN5
Q8MPN6 Q8MPN6
Q8MPN7 Q8MPN7
Q8MPN8 Q8MPN8
Q8T0M5 Q8T0M5
Q9U1I5 Q9U1I5

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