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Anapc11 anaphase promoting complex subunit 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498030, updated on 4-Jan-2025

Summary

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Official Symbol
Anapc11provided by RGD
Official Full Name
anaphase promoting complex subunit 11provided by RGD
Primary source
RGD:1561880
See related
EnsemblRapid:ENSRNOG00000036686 AllianceGenome:RGD:1561880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561880
Summary
Predicted to enable cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC11 (anaphase promoting complex subunit 11). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 67.9), Brain (RPKM 59.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Anapc11 in Genome Data Viewer
Location:
10q32.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106373610..106384633)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105875209..105886307)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109774779..109785877)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene Aly/REF export factor Neighboring gene neuropeptide B Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene sirtuin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Tang Z, et al. Mol Biol Cell, 2001 Dec. PMID 11739784, Free PMC Article
  2. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
  3. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Ohta T, et al. Mol Cell, 1999 Apr. PMID 10230407
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein branched polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126082.1 → NP_001119554.1  anaphase-promoting complex subunit 11

    See identical proteins and their annotated locations for NP_001119554.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HLF9, D3ZXH8
    Related
    ENSRNOP00000051837.4, ENSRNOT00000054954.6
    Conserved Domains (1) summary
    cl17238
    Location:1 → 84
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106373610..106384633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247906.5 → XP_006247968.1  anaphase-promoting complex subunit 11 isoform X1

    See identical proteins and their annotated locations for XP_006247968.1

    UniProtKB/TrEMBL
    A6HLF9, D3ZXH8
    Conserved Domains (1) summary
    cl17238
    Location:1 → 84
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version

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