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Nlk nemo like kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 497961, updated on 27-Nov-2024

Summary

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Official Symbol
Nlkprovided by RGD
Official Full Name
nemo like kinaseprovided by RGD
Primary source
RGD:1561602
See related
EnsemblRapid:ENSRNOG00000071257 AllianceGenome:RGD:1561602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561602
Summary
Predicted to enable several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including negative regulation of signal transduction; protein phosphorylation; and protein stabilization. Predicted to act upstream of or within protein autophosphorylation. Predicted to be active in cytoplasm and nucleus. Biomarker of myocardial infarction. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 166.6), Brain (RPKM 158.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nlk in Genome Data Viewer
Location:
10q25
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63965432..64089006, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63467388..63590960, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65840052..65963932, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene transmembrane protein 97 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like Neighboring gene cyclin Q Neighboring gene LYR motif containing 9 like 1 Neighboring gene LYR motif containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of Nemo-like kinase after spinal cord injury in rats. Xu D, et al. J Mol Neurosci, 2014 Mar. PMID 24395089
  2. Expression of Nemo-like kinase (NLK) in the brain in a rat experimental subarachnoid hemorrhage model. Chen G, et al. Cell Biochem Biophys, 2013 Jul. PMID 23325309
  3. Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried Cardiomyocytes. Yan X, et al. Cell Physiol Biochem, 2016. PMID 27577116
  4. MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK). Huang Y, et al. Curr Pharm Des, 2016. PMID 26861724
  5. Nemo-like kinase (NLK) involves in neuronal apoptosis after traumatic brain injury. Li Z, et al. Cell Mol Neurobiol, 2012 Apr. PMID 22127415

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-208a can promote Ang II-induced cardiomyocyte apoptosis via negatively regulating NLK expression, and inhibition of miR-208a may provide a novel therapeutic target for cardiomyocyte apoptosis
    Title: MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK).
  2. The results showed that NLK was a direct target of mir-208.
    Title: Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried Cardiomyocytes.
  3. NLK is decreasingly expressed in an opposite time-course to the development of cerebral vasospasm (CVS) and SAH-induced brain injury
    Title: Expression of Nemo-like kinase (NLK) in the brain in a rat experimental subarachnoid hemorrhage model.
  4. A significant down-regulation is found with nemo-like kinase and a concomitant up-regulation of caspase-3 during the early stage of traumatic brain injury.
    Title: Nemo-like kinase (NLK) involves in neuronal apoptosis after traumatic brain injury.
  5. Nlk2 gene and Nlkp pseudogene were predicted as retrotransposed Nlk homologs within the rat genome. Nlk2 gene encoded a 480-aa Nlk2 protein with partial deletion within the kinase domain, which was predicted as the dominant negative Nlk homolog.
    Title: Comparative genomics on nemo-like kinase gene.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase NLK
NP_001178853.1
XP_038942542.1
XP_063125709.1
XP_063125710.1
XP_063125711.1
XP_063125712.1
XP_063125713.1
XP_063125714.1
XP_063125715.1
XP_063125716.1
XP_063125718.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191924.3 → NP_001178853.1  serine/threonine-protein kinase NLK

    See identical proteins and their annotated locations for NP_001178853.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    D3ZSZ3
    UniProtKB/TrEMBL
    A0A8I6AN12
    Related
    ENSRNOP00000098263.1, ENSRNOT00000120628.2
    Conserved Domains (1) summary
    cd07853
    Location:137 → 508
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    63965432..64089006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086614.2 → XP_038942542.1  serine/threonine-protein kinase NLK isoform X1

    UniProtKB/Swiss-Prot
    D3ZSZ3
    UniProtKB/TrEMBL
    A0A8I6AN12
    Conserved Domains (1) summary
    cd07853
    Location:137 → 508
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

  2. XM_063269645.1 → XP_063125715.1  serine/threonine-protein kinase NLK isoform X3

  3. XM_063269644.1 → XP_063125714.1  serine/threonine-protein kinase NLK isoform X3

  4. XM_063269646.1 → XP_063125716.1  serine/threonine-protein kinase NLK isoform X4

  5. XM_063269643.1 → XP_063125713.1  serine/threonine-protein kinase NLK isoform X3

  6. XM_063269641.1 → XP_063125711.1  serine/threonine-protein kinase NLK isoform X3

  7. XM_063269640.1 → XP_063125710.1  serine/threonine-protein kinase NLK isoform X3

  8. XM_063269642.1 → XP_063125712.1  serine/threonine-protein kinase NLK isoform X3

  9. XM_063269639.1 → XP_063125709.1  serine/threonine-protein kinase NLK isoform X2

    UniProtKB/TrEMBL
    A6HH68

  10. XM_063269648.1 → XP_063125718.1  serine/threonine-protein kinase NLK isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZSZ3.1 GenPept UniProtKB/Swiss-Prot:D3ZSZ3

Gene LinkOut

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