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Ovca2 OVCA2 serine hydrolase domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 497954, updated on 27-Nov-2024

Summary

Official Symbol
Ovca2provided by RGD
Official Full Name
OVCA2 serine hydrolase domain containingprovided by RGD
Primary source
RGD:1564623
See related
AllianceGenome:RGD:1564623
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564623
Summary
Predicted to enable hydrolase activity; iron-sulfur cluster binding activity; and metal ion binding activity. Predicted to be involved in response to retinoic acid. Predicted to be located in mitochondrion and nucleus. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 47.6), Thymus (RPKM 47.6) and 9 other tissues See more
Orthologs
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Genomic context

See Ovca2 in Genome Data Viewer
Location:
10q24
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60524385..60527547, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60026048..60029211, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62017347..62020509, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095261 Neighboring gene microRNA 132 Neighboring gene diphthamide biosynthesis 1 Neighboring gene reticulon 4 receptor-like 1 Neighboring gene uncharacterized LOC120095264 Neighboring gene ATP synthase subunit g, mitochondrial-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in protein histidyl modification to diphthamide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
esterase OVCA2
Names
candidate tumor suppressor in ovarian cancer 2
ovarian tumor suppressor candidate 2
NP_001102506.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109036.1NP_001102506.1  esterase OVCA2

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I6A111, A6HGP6
    Conserved Domains (2) summary
    COG0596
    Location:20227
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03959
    Location:6218
    FSH1; Serine hydrolase (FSH1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    60524385..60527547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)