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gja12.2 gap junction protein alpha 12.2 [ Danio rerio (zebrafish) ]

Gene ID: 497173, updated on 4-Jan-2025

Summary

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Official Symbol
gja12.2provided by ZNC
Official Full Name
gap junction protein alpha 12.2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070320-1
See related
Ensembl:ENSDARG00000041792 AllianceGenome:ZFIN:ZDB-GENE-070320-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cx20d; gjadp; cx28.1; cx28.1p; si:dkey-261a18.4
Summary
Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell communication. Predicted to be located in plasma membrane. Predicted to be part of connexin complex. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See gja12.2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (40737343..40740876)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (40840219..40843665)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene gap junction protein alpha 1b Neighboring gene gap junction protein alpha 13.2 Neighboring gene gap junction protein, alpha 12.1 Neighboring gene gap junction protein alpha 13.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins. Iovine MK, et al. Dev Biol, 2005 Feb 1. PMID 15649473
  2. Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. Mikalsen SO, et al. BMC Genomics, 2020 Mar 11. PMID 32160866, Free PMC Article
  3. Evolutionary selection pressure and family relationships among connexin genes. Cruciani V, et al. Biol Chem, 2007 Mar. PMID 17338632
  4. Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Eastman SD, et al. Genomics, 2006 Feb. PMID 16337772
  5. The minimal gap-junction network among melanophores and xanthophores required for stripe pattern formation in zebrafish. Usui Y, et al. Development, 2019 Nov 15. PMID 31666235

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of connexin complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gap junction Cx32.2 protein
Names
gap junction protein, alpha d
novel connexin family protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    40737343..40740876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170194.5 → XP_005170251.1  gap junction Cx32.2 protein

    UniProtKB/TrEMBL
    A0A8M2BI04, Q5TYN8
    Related
    ENSDARP00000061250.5, ENSDART00000061251.6
    Conserved Domains (3) summary
    smart00037
    Location:44 → 76
    CNX; Connexin homologues
    smart01089
    Location:151 → 218
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3 → 220
    Connexin; Connexin
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials