slc6a5 solute carrier family 6 member 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc6a5provided by ZNC
Official Full Name: solute carrier family 6 member 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-050105-2
See related: Ensembl:ENSDARG00000067964 AllianceGenome:ZFIN:ZDB-GENE-050105-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: glyt2; si:dkey-7n10.12
Summary: Predicted to enable glycine:sodium symporter activity. Predicted to be involved in glycine import across plasma membrane; glycinergic synaptic transmission; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system and glycinergic neurons. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (17229282..17252103)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (16974960..16995846)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.
Title: The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.
A few groups of GLYT2(-) cells were observed in the midbrain and forebrain, including numerous pinealocytes
Title: Distribution of glycinergic neurons in the brain of glycine transporter-2 transgenic Tg(glyt2:Gfp) adult zebrafish: relationship to brain-spinal descending systems.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glycine:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glycinergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium- and chloride-dependent glycine transporter 2

Names: glycine transporter 2; solute carrier family 6 (neurotransmitter transporter), member 5; solute carrier family 6 (neurotransmitter transporter, glycine), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009557.1 → NP_001009557.1 sodium- and chloride-dependent glycine transporter 2

See identical proteins and their annotated locations for NP_001009557.1

Status: PROVISIONAL

Source sequence(s)

AB183389

UniProtKB/TrEMBL

B3DFM7, K7DXY4, Q5W8I5

Related

ENSDARP00000088755.4, ENSDART00000097982.6

Conserved Domains (1) summary

cl00456
Location:177 → 775

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

17229282..17252103

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302965.4 → XP_009301240.1 sodium- and chloride-dependent glycine transporter 2 isoform X1

UniProtKB/TrEMBL

A0A2R8Q8E9, A0A8M3B0Z1

Related

ENSDARP00000147557.1, ENSDART00000184910.1

Conserved Domains (1) summary

cl00456
Location:169 → 767

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain