Ccdc8 coiled-coil domain containing 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccdc8provided by RGD
Official Full Name: coiled-coil domain containing 8provided by RGD
Primary source: RGD:1359717
See related: EnsemblRapid:ENSRNOG00000027936 AllianceGenome:RGD:1359717
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in microtubule cytoskeleton organization and regulation of mitotic nuclear division. Predicted to be located in several cellular components, including centrosome; cytosol; and nucleoplasm. Predicted to be part of 3M complex. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human CCDC8 (coiled-coil domain containing 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86807607..86810935)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (77679521..77682849)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78933372..78936700)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH140147 (e-PCR)
- UniSTS:222226

RH136784 (e-PCR)
- UniSTS:218873

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of 3M complex	IBA Inferred from Biological aspect of Ancestor more info
part_of 3M complex	IEA Inferred from Electronic Annotation more info
part_of 3M complex	ISO Inferred from Sequence Orthology more info
part_of 3M complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coiled-coil domain-containing protein 8

Names: probable Coiled-coil domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009533.2 → NP_001009533.2 coiled-coil domain-containing protein 8

Status: VALIDATED

Source sequence(s)

BC060520, JAXUCZ010000001

UniProtKB/Swiss-Prot

P62521, Q6P9Z5

UniProtKB/TrEMBL

A0A0G2JTP3

Related

ENSRNOP00000068789.2, ENSRNOT00000029810.7

Conserved Domains (1) summary

pfam14893
Location:2 → 95

PNMA; PNMA