nsun4 NOP2/Sun RNA methyltransferase 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nsun4provided by ZNC
Official Full Name: NOP2/Sun RNA methyltransferase 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-77
See related: Ensembl:ENSDARG00000021324 AllianceGenome:ZFIN:ZDB-GENE-041212-77
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101708; CH73-222E2.2
Summary: Predicted to enable RNA binding activity and RNA methyltransferase activity. Predicted to act upstream of or within RNA methylation. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (10160510..10169433)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (10362664..10371859)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-methylcytosine rRNA methyltransferase NSUN4

Names: NOL1/NOP2/Sun domain family, member 4

NP_001008649.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008649.1 → NP_001008649.1 5-methylcytosine rRNA methyltransferase NSUN4

See identical proteins and their annotated locations for NP_001008649.1

Status: PROVISIONAL

Source sequence(s)

BC086725

UniProtKB/TrEMBL

A0A8M9Q8A2, Q5PRB6

Related

ENSDARP00000115280.1, ENSDART00000136018.2

Conserved Domains (1) summary

cl17173
Location:109 → 269

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...