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arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b [ Danio rerio (zebrafish) ]

Gene ID: 494081, updated on 9-Dec-2024

Summary

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Official Symbol
arhgef7bprovided by ZNC
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 7bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041212-49
See related
Ensembl:ENSDARG00000073848 AllianceGenome:ZFIN:ZDB-GENE-041212-49
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bbh; bpix; arhgef7; im:7142367; wu:fc35h08; zgc:101775
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including endothelial cell proliferation; epiboly involved in gastrulation with mouth forming second; and protein localization to adherens junction. Predicted to be active in cytoplasm and lamellipodium. Is expressed in several structures, including EVL; axial vasculature; hatching gland; nervous system; and periderm. Used to study cerebrovascular disease. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See arhgef7b in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (45958906..46020725)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (45266965..45329148)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene lipoyltransferase 1 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene uncharacterized LOC103909161 Neighboring gene E3 ubiquitin-protein ligase RNF12-B-like Neighboring gene uncharacterized LOC137495286

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RNA-Seq Dataset From Isolated Leukocytes Following Spontaneous Intracerebral Hemorrhage in Zebrafish Larvae. Crilly S, et al. Front Cell Neurosci, 2021. PMID 33935655, Free PMC Article
  2. Zebrafish drug screening identifies candidate therapies for neuroprotection after spontaneous intracerebral haemorrhage. Crilly S, et al. Dis Model Mech, 2022 Mar 1. PMID 35098999, Free PMC Article
  3. Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke. Crilly S, et al. J Vis Exp, 2019 Jun 5. PMID 31233021
  4. βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8. Liu J, et al. Dev Biol, 2012 Mar 1. PMID 22206757
  5. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Liu J, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17573532, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to adherens junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 7b
Names
Rho guanine exchange factor betaPix

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008624.1 → NP_001008624.1  rho guanine nucleotide exchange factor 7b

    See identical proteins and their annotated locations for NP_001008624.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086736
    UniProtKB/TrEMBL
    Q5PRA8
    Related
    ENSDARP00000100870.2, ENSDART00000108528.4
    Conserved Domains (9) summary
    cd11877
    Location:166 → 218
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    COG5199
    Location:1 → 170
    SCP1; Calponin [Cytoskeleton]
    cd01225
    Location:458 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:476 → 556
    PH; PH domain
    pfam00307
    Location:31 → 105
    CH; Calponin homology (CH) domain
    pfam00621
    Location:253 → 428
    RhoGEF; RhoGEF domain
    pfam16523
    Location:710 → 796
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:609 → 707
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115 → 162
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    45958906..46020725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354714.3 → XP_017210203.1  rho guanine nucleotide exchange factor 7b isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5N5

  2. XM_021474150.2 → XP_021329825.1  rho guanine nucleotide exchange factor 7b isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q952
    Conserved Domains (7) summary
    cd11877
    Location:166 → 218
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00307
    Location:2 → 105
    CH; Calponin homology (CH) domain
    pfam16523
    Location:753 → 839
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:609 → 707
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115 → 162
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  3. XM_017354716.3 → XP_017210205.1  rho guanine nucleotide exchange factor 7b isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z512

  4. XM_017354718.3 → XP_017210207.1  rho guanine nucleotide exchange factor 7b isoform X4

    UniProtKB/TrEMBL
    A0A8M6YXL6, F1QA07
    Related
    ENSDARP00000042085.5, ENSDART00000042086.6
Nucleotide Protein Strain
Heading Accession and Version

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