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dhtkd1 dehydrogenase E1 and transketolase domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 494076, updated on 9-Dec-2024

Summary

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Official Symbol
dhtkd1provided by ZNC
Official Full Name
dehydrogenase E1 and transketolase domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041212-44
See related
Ensembl:ENSDARG00000016415 AllianceGenome:ZFIN:ZDB-GENE-041212-44
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
E1a; OADC-E1; OADH-E1; zgc:101818
Summary
Predicted to enable 2-oxoadipate dehydrogenase activity and thiamine pyrophosphate binding activity. Predicted to act upstream of or within glycolytic process. Predicted to be located in mitochondrion. Is expressed in alar plate midbrain region; eye; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See dhtkd1 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8031999..8055229, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (7907907..7931137, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene upper zone of growth plate and cartilage matrix associated b Neighboring gene calcium/calmodulin-dependent protein kinase 1Db Neighboring gene potassium voltage-gated channel, Shaw-related subfamily, member 1b Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A ΔRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. He S, et al. J Pathol, 2011 Sep. PMID 21744342
  2. Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity. Lin SJ, et al. Genome Med, 2023 Nov 29. PMID 38031187, Free PMC Article
  3. Comparative Proteome Research in a Zebrafish Model for Vanishing White Matter Disease. Kim D, et al. Int J Mol Sci, 2021 Mar 8. PMID 33800130, Free PMC Article
  4. Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Wang Y, et al. Funct Integr Genomics, 2011 Mar. PMID 21052758
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 2-oxoadipate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-oxoadipate dehydrogenase complex component E1
Names
2-oxoadipate dehydrogenase, mitochondrial
alpha-KADH-E1
alpha-ketoadipate dehydrogenase
dehydrogenase E1 and transketolase domain-containing protein 1
probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
NP_001008619.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008619.1 → NP_001008619.1  2-oxoadipate dehydrogenase complex component E1

    See identical proteins and their annotated locations for NP_001008619.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086742
    UniProtKB/Swiss-Prot
    Q5PRA2
    Related
    ENSDARP00000025776.6, ENSDART00000003252.8
    Conserved Domains (4) summary
    PRK09404
    Location:43 → 925
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:182 → 455
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:574 → 777
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16870
    Location:785 → 924
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    8031999..8055229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395187.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    603..11759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PRA2.2 GenPept UniProtKB/Swiss-Prot:Q5PRA2

Gene LinkOut

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