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oclnb occludin b [ Danio rerio (zebrafish) ]

Gene ID: 494075, updated on 9-Dec-2024

Summary

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Official Symbol
oclnbprovided by ZNC
Official Full Name
occludin bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041212-43
See related
Ensembl:ENSDARG00000003091 AllianceGenome:ZFIN:ZDB-GENE-041212-43
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fk83f10; zgc:101820
Summary
Predicted to enable thiopurine S-methyltransferase activity. Predicted to be involved in bicellular tight junction assembly. Predicted to be located in anchoring junction and plasma membrane. Predicted to be active in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including EVL; digestive system; extension; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See oclnb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26212626..26220720)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25612420..25620571)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:86811 Neighboring gene MARVEL domain containing 2b Neighboring gene general transcription factor IIH, polypeptide 2 Neighboring gene endoplasmic reticulum aminopeptidase 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Chen Z, et al. Front Microbiol, 2020. PMID 32670209, Free PMC Article
  2. Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles. Clelland ES, et al. Gen Comp Endocrinol, 2011 Apr 1. PMID 21291886
  3. Dietary nucleotides can directly stimulate the immunity of zebrafish independent of the intestinal microbiota. Guo X, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30590163
  4. Thymol and Carvacrol Affect Hybrid Tilapia through the Combination of Direct Stimulation and an Intestinal Microbiota-Mediated Effect: Insights from a Germ-Free Zebrafish Model. Ran C, et al. J Nutr, 2016 May. PMID 27075912
  5. Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Solis CJ, et al. Front Immunol, 2020. PMID 32793187, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables thiopurine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
occludin b
NP_001008618.1
XP_005171901.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008618.1 → NP_001008618.1  occludin b

    See identical proteins and their annotated locations for NP_001008618.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086743
    UniProtKB/TrEMBL
    Q5PRA1
    Related
    ENSDARP00000089285.2, ENSDART00000098514.3
    Conserved Domains (2) summary
    pfam07303
    Location:363 → 458
    Occludin_ELL; Occludin homology domain
    pfam14584
    Location:237 → 266
    DUF4446; Protein of unknown function (DUF4446)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    26212626..26220720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171844.5 → XP_005171901.1  occludin b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BJ48, A2BGQ3
    Related
    ENSDARP00000116151.1, ENSDART00000134432.3
    Conserved Domains (2) summary
    pfam07303
    Location:373 → 468
    Occludin_ELL; Occludin homology domain
    pfam14584
    Location:244 → 273
    DUF4446; Protein of unknown function (DUF4446)
Nucleotide Protein
Heading Accession and Version

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