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dhodh dihydroorotate dehydrogenase [ Danio rerio (zebrafish) ]

Gene ID: 494065, updated on 9-Dec-2024

Summary

Official Symbol
dhodhprovided by ZNC
Official Full Name
dihydroorotate dehydrogenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3157
See related
Ensembl:ENSDARG00000051889 AllianceGenome:ZFIN:ZDB-GENE-030131-3157
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc29a01; zgc:103492
Summary
Predicted to enable dihydroorotate dehydrogenase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleotide biosynthetic process. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See dhodh in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (56517402..56529527)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (56215991..56228116)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene IST1 factor associated with ESCRT-III Neighboring gene polycystic kidney disease 1-like 3 Neighboring gene trace amine-associated receptor 13c-like Neighboring gene haptoglobin

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dihydroorotate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
 
enables dihydroorotate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dihydroorotate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyrimidine ribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dihydroorotate dehydrogenase (quinone), mitochondrial
NP_001008608.1
XP_005166619.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008608.1NP_001008608.1  dihydroorotate dehydrogenase (quinone), mitochondrial

    See identical proteins and their annotated locations for NP_001008608.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086819
    UniProtKB/TrEMBL
    Q5PR57
    Related
    ENSDARP00000068087.3, ENSDART00000073597.4
    Conserved Domains (2) summary
    PLN02826
    Location:15393
    PLN02826; dihydroorotate dehydrogenase
    cd04738
    Location:44372
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    56517402..56529527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166562.4XP_005166619.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M2BE38
    Conserved Domains (2) summary
    PLN02826
    Location:15392
    PLN02826; dihydroorotate dehydrogenase
    cd04738
    Location:44371
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

RNA

  1. XR_662224.2 RNA Sequence

  2. XR_011016165.1 RNA Sequence