cavin4b caveolae associated protein 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cavin4bprovided by ZNC
Official Full Name: caveolae associated protein 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-87
See related: Ensembl:ENSDARG00000056743 AllianceGenome:ZFIN:ZDB-GENE-041212-87
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: murc; murcb; zgc:92239; wu:fc18g06
Summary: Acts upstream of or within T-tubule organization and skeletal muscle fiber development. Predicted to be located in membrane. Predicted to be active in caveola and cytoplasm. Is expressed in several structures, including adaxial cell; dorsal habenular nucleus; musculature system; pectoral fin bud; and somite. Used to study muscular dystrophy. Orthologous to human CAVIN4 (caveolae associated protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (33697831..33703380, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (33811656..33817205, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

murcb mutant zebrafish, display impaired swimming capacity, skeletal muscle fibrosis and T-tubule abnormalities during development.
Title: Cavin4b/Murcb Is Required for Skeletal Muscle Development and Function in Zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-tubule organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: caveolae-associated protein 4b

Names: muscle-related coiled-coil protein b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.