lonp2 lon peptidase 2, peroxisomal [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lonp2provided by ZNC
Official Full Name: lon peptidase 2, peroxisomalprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-1
See related: Ensembl:ENSDARG00000101438 AllianceGenome:ZFIN:ZDB-GENE-041212-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92557; wu:fc51e03
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and peptidase activity. Predicted to be involved in protein processing and protein targeting to peroxisome. Predicted to act upstream of or within protein catabolic process and proteolysis. Predicted to be located in peroxisome. Predicted to be active in peroxisomal matrix. Orthologous to human LONP2 (lon peptidase 2, peroxisomal). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (18475674..18524624, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (18486608..18535558, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

z33808 (e-PCR), detects polymorphism
- UniSTS:238857

fd99a11.x1 (e-PCR)
- UniSTS:195852

fc27c02.y1 (e-PCR)
- UniSTS:193350

fc51e03 (e-PCR)
- UniSTS:189292

fb81f05.x1 (e-PCR)
- UniSTS:191641

fb81f05.x1 (e-PCR)
- UniSTS:191642

fc48f09.y1 (e-PCR)
- UniSTS:193993

fi25c05.x1 (e-PCR)
- UniSTS:197100

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein quality control for misfolded or incompletely synthesized proteins	IEA Inferred from Electronic Annotation more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to peroxisome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lon protease homolog 2, peroxisomal

NP_001008573.1

EC 3.4.21.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008573.2 → NP_001008573.1 lon protease homolog 2, peroxisomal

See identical proteins and their annotated locations for NP_001008573.1

Status: PROVISIONAL

Source sequence(s)

BC086968

UniProtKB/Swiss-Prot

Q5PQY6

Related

ENSDARP00000140082.1, ENSDART00000157834.2

Conserved Domains (4) summary

COG0466
Location:4 → 826

Lon; ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]

cl19481
Location:9 → 225

LON; Found in ATP-dependent protease La (LON)

pfam00004
Location:371 → 513

AAA; ATPase family associated with various cellular activities (AAA)

cl21678
Location:618 → 825

ChlI; Subunit ChlI of Mg-chelatase