NLRP5 NLR family pyrin domain containing 5 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: NLRP5provided by VGNC
Official Full Name: NLR family pyrin domain containing 5provided by VGNC
Primary source: VGNC:VGNC:32118
See related: BGD:BT29995; Ensembl:ENSBTAG00000013247
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MATER; NALP5
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (63478435..63493230)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Assignment to a QTL region for reproductive traits and preferential expression of NALP9, NALP8, and NALP5 in oocyte, germinal lineage, and gonad cells may suggest their functional relevance to reproduction and possible contribution to phenotypic variation
Title: Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos.
expression patterns are consistent with bovine MATER protein being an oocyte specific maternal effect factor as in mouse
Title: MATER protein expression and intracellular localization throughout folliculogenesis and preimplantation embryo development in the bovine.
In situ hybridization confirmed oocyte-restricted expression of MATER within the ovary, as early as preantral follicle stages.
Title: Spatio-temporal expression of the germ cell marker genes MATER, ZAR1, GDF9, BMP15,andVASA in adult bovine tissues, oocytes, and preimplantation embryos.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
part_of subcortical maternal complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 5

Names: NACHT, leucine rich repeat and PYD containing 5; mater protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007814.2 → NP_001007815.1 NACHT, LRR and PYD domains-containing protein 5

See identical proteins and their annotated locations for NP_001007815.1

Status: PROVISIONAL

Source sequence(s)

AY721594

UniProtKB/Swiss-Prot

Q647I9

UniProtKB/TrEMBL

F1MT67

Related

ENSBTAP00000017623.6, ENSBTAT00000017623.6

Conserved Domains (5) summary

smart00382
Location:178 → 302

AAA; ATPases associated with a variety of cellular activities

cd00116
Location:796 → 1057

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:14 → 97

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00034
Location:824 → 851

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:181 → 343

NACHT; NACHT domain