amh anti-Mullerian hormone [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: amhprovided by ZNC
Official Full Name: anti-Mullerian hormoneprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050706-192
See related: Ensembl:ENSDARG00000014357 AllianceGenome:ZFIN:ZDB-GENE-050706-192
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable growth factor activity. Acts upstream of or within several processes, including negative regulation of androgen secretion; regulation of ovarian follicle development; and sperm capacitation. Predicted to be located in extracellular region. Is expressed in female organism; granulosa cell; male organism; and reproductive system. Human ortholog(s) of this gene implicated in disorder of sexual development; ovarian carcinoma; and persistent Mullerian duct syndrome. Orthologous to human AMH (anti-Mullerian hormone). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (20748151..20761901, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (20723474..20736818, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anti-Mullerian hormone (Amh/amh) plays dual roles in maintaining gonadal homeostasis and gametogenesis in zebrafish.
Title: Anti-Müllerian hormone (Amh/amh) plays dual roles in maintaining gonadal homeostasis and gametogenesis in zebrafish.
Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signaling through Bmpr2a receptor.
Title: Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signaling through Bmpr2a receptor.
These results show that ancestral Amh functions included development of the gonadal soma in ovaries and testes and regulation of gamete proliferation and maturation. A major gap in our understanding is the identity of the gene encoding a zebrafish Amh receptor; we show here that the loss of amhr2 is associated with the breakpoint of a chromosome rearrangement shared among cyprinid fishes.
Title: A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination.
Gdf9 significantly suppressed the expression of amh while increased that of activin beta subunits (inhbaa and inhbb) in vitro.
Title: Expression analysis of growth differentiation factor 9 (Gdf9/gdf9), anti-müllerian hormone (Amh/amh) and aromatase (Cyp19a1a/cyp19a1a) during gonadal differentiation of the zebrafish, Danio rerio.
These data suggest that an important aspect of Fsh bioactivity in stimulating spermatogenesis is implemented by restricting the different inhibitory effects of Amh and by counterbalancing them with stimulatory signals, such as Igf3.
Title: Antagonistic regulation of spermatogonial differentiation in zebrafish (Danio rerio) by Igf3 and Amh.
amh controls the balance between proliferation and differentiation of male germ cells.
Title: Distinct and Cooperative Roles of amh and dmrt1 in Self-Renewal and Differentiation of Male Germ Cells in Zebrafish.
nuclear receptor subfamily 5, group A, member 1b is a new candidate for sex determination and differentiation in a way similar to steroidogenic factor 1, possibly involving AMH
Title: Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish.
zebrafish Anti-Mullerian hormone (Amh) is regulated by sox9a, sox9b, and cyp19a1a during gonad development
Title: Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development.
amh is a candidate gene down-regulating cyp19a1a, leading to "juvenile ovary-to-testis" transformation.
Title: Anti-Müllerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within development of primary male sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of androgen secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: muellerian-inhibiting factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007779.1 → NP_001007780.1 muellerian-inhibiting factor precursor

See identical proteins and their annotated locations for NP_001007780.1

Status: PROVISIONAL

Source sequence(s)

AY721604

UniProtKB/TrEMBL

Q647I8, Q6B6Q2

Conserved Domains (2) summary

pfam00019
Location:455 → 548

TGF_beta; Transforming growth factor beta like domain

pfam04709
Location:74 → 439

AMH_N; Anti-Mullerian hormone, N terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

20748151..20761901 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009296234.4 → XP_009294509.1 muellerian-inhibiting factor isoform X1

UniProtKB/TrEMBL

A0A8M3AXM8, A8E7B8

Related

ENSDARP00000015395.7, ENSDART00000013803.8

Conserved Domains (2) summary

pfam00019
Location:455 → 548

TGF_beta; Transforming growth factor beta like domain

pfam04709
Location:74 → 439

AMH_N; Anti-Mullerian hormone, N terminal region