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glyr1 glyoxylate reductase 1 homolog (Arabidopsis) [ Danio rerio (zebrafish) ]

Gene ID: 493611, updated on 4-Jan-2025

Summary

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Official Symbol
glyr1provided by ZNC
Official Full Name
glyoxylate reductase 1 homolog (Arabidopsis)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041121-5
See related
Ensembl:ENSDARG00000099213 AllianceGenome:ZFIN:ZDB-GENE-041121-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
NPAC; fb96g02; wu:fb96g02; zgc:103629
Summary
Predicted to enable DNA binding activity; methylated histone binding activity; and nucleosome binding activity. Predicted to be involved in transcription elongation-coupled chromatin remodeling. Predicted to be located in chromatin. Orthologous to human GLYR1 (glyoxylate reductase 1 homolog). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See glyr1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36441405..36458165, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36299538..36316341, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-443f11.2 Neighboring gene rogdi atypical leucine zipper Neighboring gene periplakin Neighboring gene si:dkeyp-72e1.9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transcription elongation-coupled chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytokine-like nuclear factor N-PAC
Names
nuclear protein NP60
putative oxidoreductase GLYR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007771.1 → NP_001007772.1  cytokine-like nuclear factor N-PAC

    See identical proteins and their annotated locations for NP_001007772.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085567
    UniProtKB/Swiss-Prot
    Q5RKN4
    UniProtKB/TrEMBL
    B2GT29
    Related
    ENSDARP00000137468.1, ENSDART00000167741.2
    Conserved Domains (4) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:176 → 460
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    pfam03446
    Location:176 → 335
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    pfam14833
    Location:339 → 460
    NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    36441405..36458165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216802.1 → XP_068072903.1  cytokine-like nuclear factor N-PAC isoform X6

  2. XM_068216801.1 → XP_068072902.1  cytokine-like nuclear factor N-PAC isoform X5

  3. XM_068216799.1 → XP_068072900.1  cytokine-like nuclear factor N-PAC isoform X4

  4. XM_021470489.2 → XP_021326164.1  cytokine-like nuclear factor N-PAC isoform X3

    UniProtKB/TrEMBL
    A0A8M9PMQ5
    Conserved Domains (2) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:204 → 488
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

  5. XM_005164105.5 → XP_005164162.1  cytokine-like nuclear factor N-PAC isoform X2

    UniProtKB/TrEMBL
    A0A8M2BBE0
    Conserved Domains (4) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:222 → 505
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    pfam03446
    Location:222 → 383
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    pfam14833
    Location:384 → 505
    NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

  6. XM_005164104.5 → XP_005164161.1  cytokine-like nuclear factor N-PAC isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBK6
    Conserved Domains (4) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:222 → 506
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    pfam03446
    Location:222 → 381
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    pfam14833
    Location:385 → 506
    NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RKN4.1 GenPept UniProtKB/Swiss-Prot:Q5RKN4

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