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cdca8 cell division cycle associated 8 [ Danio rerio (zebrafish) ]

Gene ID: 492815, updated on 9-Dec-2024

Summary

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Official Symbol
cdca8provided by ZNC
Official Full Name
cell division cycle associated 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-171
See related
Ensembl:ENSDARG00000043137 AllianceGenome:ZFIN:ZDB-GENE-041114-171
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb373; cdca8l; sb:cb373; zgc:101607
Summary
Acts upstream of or within heart development. Predicted to be located in several cellular components, including chromosome; cytoskeleton; and nucleus. Predicted to be part of chromosome passenger complex. Predicted to be active in chromosome, centromeric region and spindle midzone. Is expressed in proliferative region. Orthologous to human CDCA8 (cell division cycle associated 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See cdca8 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (47773015..47782876, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (48144919..48154856)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD94 Neighboring gene ephrin type-A receptor 7 Neighboring gene ribonucleotide reductase M2 polypeptide Neighboring gene claudin 35 Neighboring gene AFG2 interacting ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Sampath SC, et al. Cell, 2004 Jul 23. PMID 15260989
  2. Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. Hsu AY, et al. Proc Natl Acad Sci U S A, 2019 Sep 10. PMID 31451657, Free PMC Article
  3. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Milan DJ, et al. Circulation, 2009 Aug 18. PMID 19652097, Free PMC Article
  4. Transcriptomic profile of early zebrafish PGCs by single cell sequencing. Zhang X, et al. PLoS One, 2019. PMID 31412047, Free PMC Article
  5. Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. Wang C, et al. BMC Genom Data, 2022 May 31. PMID 35641933, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromosome passenger complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
borealin
Names
Dasra B
DrDasraB
cell division cycle-associated protein 8
dasra-B
dasraB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007456.1 → NP_001007457.1  borealin

    See identical proteins and their annotated locations for NP_001007457.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085383
    UniProtKB/Swiss-Prot
    Q5U3V2, Q5XLR4
    UniProtKB/TrEMBL
    B2GQ71
    Related
    ENSDARP00000063336.6, ENSDART00000063337.8
    Conserved Domains (2) summary
    pfam10444
    Location:22 → 76
    Nbl1_Borealin_N; Nbl1 / Borealin N terminal
    pfam10512
    Location:161 → 274
    Borealin; Cell division cycle-associated protein 8

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    47773015..47782876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215121.1 → XP_068071222.1  borealin isoform X2

    UniProtKB/TrEMBL
    A0A8M6YUH5

  2. XM_017352229.3 → XP_017207718.1  borealin isoform X2

    UniProtKB/TrEMBL
    A0A8M6YUH5

  3. XM_005173787.5 → XP_005173844.1  borealin isoform X1

    UniProtKB/TrEMBL
    A0A8M2BL47, F1RBV2
    Conserved Domains (2) summary
    pfam10444
    Location:22 → 76
    Nbl1_Borealin_N; Nbl1 / Borealin N terminal
    pfam10512
    Location:161 → 274
    Borealin; Cell division cycle-associated protein 8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XLR4.2 GenPept UniProtKB/Swiss-Prot:Q5XLR4

Gene LinkOut

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