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me3 malic enzyme 3, NADP(+)-dependent, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 492719, updated on 9-Dec-2024

Summary

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Official Symbol
me3provided by ZNC
Official Full Name
malic enzyme 3, NADP(+)-dependent, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041111-294
See related
Ensembl:ENSDARG00000002305 AllianceGenome:ZFIN:ZDB-GENE-041111-294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7151680; wu:fi43b04; zgc:163117
Summary
Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Is expressed in pectoral fin musculature and pronephric duct. Orthologous to human ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See me3 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34246384..34260191, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (34437199..34451006, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene mitochondrial pyruvate carrier 2b Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene immunoglobulin-like domain containing receptor 1b Neighboring gene immunoglobulin-like domain containing receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Holowiecki A, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jan. PMID 27760386, Free PMC Article
  2. Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule. Sugano Y, et al. Pflugers Arch, 2017 Aug. PMID 28656378
  3. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Zhang CY, et al. Leukemia, 2018 Feb. PMID 28642593
  4. Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac morphogenesis. Konzer A, et al. Mol Cell Proteomics, 2013 Jun. PMID 23412571, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables malic enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADP-dependent malic enzyme, mitochondrial
NP_001082825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089356.1 → NP_001082825.1  NADP-dependent malic enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_001082825.1

    Status: PROVISIONAL

    Source sequence(s)
    BC139717
    UniProtKB/TrEMBL
    A0A8M1NCY2, A4QPA0
    Related
    ENSDARP00000006882.8, ENSDART00000012385.9
    Conserved Domains (3) summary
    cd05312
    Location:304 → 580
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:47 → 587
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:113 → 294
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    34246384..34260191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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