gsto2 glutathione S-transferase omega 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gsto2provided by ZNC
Official Full Name: glutathione S-transferase omega 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-67
See related: Ensembl:ENSDARG00000033285 AllianceGenome:ZFIN:ZDB-GENE-041114-67
Gene type: protein coding
RefSeq status: PREDICTED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101897
Summary: Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to several human genes including GSTO1 (glutathione S-transferase omega 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (25396949..25402772)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (25266502..25272311)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione dehydrogenase (ascorbate) activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables methylarsonate reductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase omega-2

NP_001007373.1

EC 2.5.1.18

XP_068068938.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007372.1 → NP_001007373.1 glutathione S-transferase omega-2

See identical proteins and their annotated locations for NP_001007373.1

Status: PREDICTED

Source sequence(s)

BC085467

UniProtKB/TrEMBL

Q5U3M8

Related

ENSDARP00000041256.5, ENSDART00000041257.7

Conserved Domains (3) summary

cd03184
Location:107 → 229

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

COG0625
Location:25 → 210

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03055
Location:4 → 93

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...