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Cyp303a1 Cytochrome P450 303a1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49165, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp303a1provided by FlyBase
Official Full Name
Cytochrome P450 303a1provided by FlyBase
Primary source
FLYBASE:FBgn0001992
Locus tag
Dmel_CG4163
See related
AllianceGenome:FB:FBgn0001992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
303a1; BG:DS02740.6; CG4163; Cyp303A1; CYP303A1; CYP303A1-Dm; Dmel\CG4163; I(2)35Fb; l(2)35Fb; nompH; nompH1
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in sensory organ development. Is expressed in embryonic head; embryonic/larval tracheal section; ring gland; sense organ; and tormogen cell. Human ortholog(s) of this gene implicated in several diseases, including drug dependence (multiple); hypertension (multiple); neonatal abstinence syndrome; nicotine dependence; and renal fibrosis. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2J2 (cytochrome P450 family 2 subfamily J member 2); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cyp303a1 in Genome Data Viewer
Location:
35F1-35F1; 2-52 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16294183..16296969)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16294183..16296969)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44899 Neighboring gene uncharacterized protein Neighboring gene heixuedian Neighboring gene uncharacterized protein Neighboring gene Glia maturation factor Neighboring gene crossover suppressor on 2 of Manheim Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CYP303A1 has a conserved function in adult eclosion in Locusta migratoria and Drosophila melanogaster. Wu L, et al. Insect Biochem Mol Biol, 2019 Oct. PMID 31422152
  2. Cyp6g2 is the major P450 epoxidase responsible for juvenile hormone biosynthesis in Drosophila melanogaster. Jia Q, et al. BMC Biol, 2024 May 13. PMID 38741075, Free PMC Article
  3. Association of detoxification enzymes with butene-fipronil in larvae and adults of Drosophila melanogaster. Arain MS, et al. Environ Sci Pollut Res Int, 2018 Apr. PMID 29380196
  4. The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. Wang SP, et al. Arch Insect Biochem Physiol, 2012 Apr. PMID 22508581
  5. A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. Willingham AT, et al. Mech Dev, 2004 Oct. PMID 15327788

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 303a1
Names
CG4163-PA
CG4163-PB
Cyp303a1-PA
Cyp303a1-PB
lethal(2)35Fb
NP_001285977.1
NP_652070.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16294183..16296969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299048.1 → NP_001285977.1  cytochrome P450 303a1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285977.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V399
    UniProtKB/TrEMBL
    X2JA13
    Conserved Domains (1) summary
    pfam00067
    Location:28 → 480
    p450; Cytochrome P450

  2. NM_143813.3 → NP_652070.1  cytochrome P450 303a1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652070.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V399
    UniProtKB/TrEMBL
    X2JA13
    Related
    FBpp0080386
    Conserved Domains (1) summary
    pfam00067
    Location:28 → 480
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V399.1 Q9V399
X2JA13 X2JA13

Gene LinkOut

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