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Atpalpha - Na pump alpha subunit

Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including cell junction assembly; determination of adult lifespan; and respiratory system development. Located in basolateral plasma membrane; nucleus; and septate junction. Part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including brain; epithelial cell; organism subdivision; salivary gland; and synaptic neuropil domain. Used to study Charcot-Marie-Tooth disease type 2DD; epilepsy; familial hemiplegic migraine; and nervous system disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; bipolar disorder; brain disease (multiple); and hypertension. Orthologous to several human genes including ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa