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CkIIalpha casein kinase IIalpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48448, updated on 9-Dec-2024

Summary

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Official Symbol
CkIIalphaprovided by FlyBase
Official Full Name
casein kinase IIalphaprovided by FlyBase
Primary source
FLYBASE:FBgn0264492
Locus tag
Dmel_CG17520
See related
AllianceGenome:FB:FBgn0264492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0958/08; alphaCK2; anon-WO02059370.53; Cask-II-a; CG17520; CJIIalpha; CK II; CK-2; CK-II; CK-II alpha; CK2; CK2 alpha; CK2-alpha; CK2a; ck2alpha; Ck2alpha; CK2alpha; CkII; CKII; CKII alpha; CKII-alpha; CkIIa; CKIIa; CKIIalfa; ckIIalpha; CKIIalpha; dCK2alpha; dCKII; dCKII alpha; Dm-CK2-alpha; DmCK2alpha; DmCKIIalpha; Dmel\CG17520; l(3)S095808; Tik
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including lateral inhibition; locomotor rhythm; and positive regulation of smoothened signaling pathway. Located in cytosol and nucleus. Part of protein kinase CK2 complex. Is expressed in adult head; adult heart; adult s-LNv neurons; and spermatozoon. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1) and CSNK2A3 (casein kinase 2 alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CkIIalpha in Genome Data Viewer
Location:
80D1-80D1; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23097072..23103460)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23090172..23096560)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene neuromusculin Neighboring gene Ribosomal protein L10 Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the catalytic subunit of casein kinase II expressed in Escherichia coli and regulation of activity. Lin WJ, et al. J Biol Chem, 1991 Mar 25. PMID 1900838
  2. Inhibition of caries in hamsters treated with staphylococcin 1580. Fitzgerald RJ, et al. Infect Immun, 1986 Nov. PMID 3770944, Free PMC Article
  3. Purification and characterization of a type II casein kinase from Drosophila melanogaster. Glover CV, et al. J Biol Chem, 1983 Mar 10. PMID 6298230
  4. SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression. Zwarts L, et al. Dis Model Mech, 2017 Jun 1. PMID 28331058, Free PMC Article
  5. Casein kinase II beta-subunit inhibits the activity of the catalytic alpha-subunit in the absence of salt. Tiganis T, et al. Biochim Biophys Acta, 1993 Dec 8. PMID 8268212

See all (206) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data (including data from studies using transgenic animals) suggest that catalytic activity of casein kinase 2 (CkIIa/CkIIb) is essential for oogenesis in this species; Jabba, a lipid droplet-associated protein and substrate for casein kinase 2, is essential in modulating ovarian lipid metabolism. (CkIIa = casein kinase II alpha subunit; CkIIb = casein kinase II beta subunit)
    Title: The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis.
  2. CK2alpha might be important in regulating synaptic plasticity by modulating the transcription of BRP. Hence, we propose that CK2alpha is a novel regulator of the active zone protein, BRP, in Drosophila.
    Title: CK2α regulates the transcription of BRP in Drosophila.
  3. Coexpressing CK2alpha and CK2beta increases Smo accumulation and induces ectopic Hh target gene expression.
    Title: Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.
  4. overexpression of Tik elicits ectopic bristles in N(+) flies and suppresses the retinal defects of the gain-of-function allele N(spl).
    Title: Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.
  5. Results describe the isolation of temperature-sensitive alleles of Drosophila CK2alpha.
    Title: Drosophila protein kinase CK2 is rendered temperature-sensitive by mutations of highly conserved residues flanking the activation segment.
  6. Coimmunoprecipitation experiments revealed that the alpha-subunit of the protein kinase CK2 (CK2alpha) was associated with soluble Stellate.
    Title: Genetically Derepressed Nucleoplasmic Stellate Protein in Spermatocytes of D. melanogaster interacts with the catalytic subunit of protein kinase 2 and carries histone-like lysine-methylated mark.
  7. Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.
    Title: Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.
  8. casein kinase II has a role in regulating cAMP-response element-binding protein DNA binding by phosphorylation at specific CK sites
    Title: Phosphorylation of conserved casein kinase sites regulates cAMP-response element-binding protein DNA binding in Drosophila.
  9. CK2 alpha binds and phosphorylates ribosomal protein L22
    Title: Interaction of casein kinase II with ribosomal protein L22 of Drosophila melanogaster.
  10. Sequencing of full-length cDNA encoding subunits in platelets and megakaryocytic cells
    Title: Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aggressive behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular mRNA localization involved in pattern specification process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lateral inhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle HMP PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte dorsal/ventral axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in oocyte dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
casein kinase IIalpha
Names
CG17520-PA
CG17520-PB
CG17520-PC
CG17520-PD
CG17520-PE
CG17520-PF
CG17520-PG
CkIIalpha-PA
CkIIalpha-PB
CkIIalpha-PC
CkIIalpha-PD
CkIIalpha-PE
CkIIalpha-PF
CkIIalpha-PG
NAP1-kinase
alpha subunit of drosophila casein kinase II
casein kinase 2
casein kinase II
casein kinase II alpha
casein kinase II alpha subunit
casein kinase II-alpha subunit
lethal (3) S095808
protein kinase CK2
timekeeper
NP_001036624.1
NP_001287151.1
NP_001287152.1
NP_001287153.1
NP_524918.1
NP_730774.1
NP_730775.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    23097072..23103460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300224.1 → NP_001287153.1  casein kinase IIalpha, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287153.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181, Q0E8B4, Q9W5T2
    UniProtKB/TrEMBL
    A4V2B8
    Conserved Domains (1) summary
    cd14132
    Location:18 → 322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  2. NM_001043159.3 → NP_001036624.1  casein kinase IIalpha, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036624.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181, Q0E8B4, Q9W5T2
    UniProtKB/TrEMBL
    A4V2B8
    Conserved Domains (1) summary
    cd14132
    Location:18 → 322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  3. NM_080179.5 → NP_524918.1  casein kinase IIalpha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524918.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181, Q0E8B4, Q9W5T2
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0070042
    Conserved Domains (1) summary
    cd14132
    Location:18 → 322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  4. NM_168985.2 → NP_730774.1  casein kinase IIalpha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730774.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181, Q0E8B4, Q9W5T2
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0070041
    Conserved Domains (1) summary
    cd14132
    Location:18 → 322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  5. NM_168986.2 → NP_730775.1  casein kinase IIalpha, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181, Q0E8B4, Q9W5T2
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0070043
    Conserved Domains (1) summary
    cd14132
    Location:18 → 322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  6. NM_001300222.1 → NP_001287151.1  casein kinase IIalpha, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181, Q0E8B4, Q9W5T2
    UniProtKB/TrEMBL
    A4V2B8
    Conserved Domains (1) summary
    cd14132
    Location:18 → 322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  7. NM_001300223.1 → NP_001287152.1  casein kinase IIalpha, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287152.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181, Q0E8B4, Q9W5T2
    UniProtKB/TrEMBL
    A4V2B8
    Conserved Domains (1) summary
    cd14132
    Location:18 → 322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V2B8 A4V2B8
P08181.2 P08181

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