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Aprt Adenine phosphoribosyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48224, updated on 4-Jan-2025

Summary

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Official Symbol
Aprtprovided by FlyBase
Official Full Name
Adenine phosphoribosyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0000109
Locus tag
Dmel_CG18315
See related
AllianceGenome:FB:FBgn0000109
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aprt; APRT; BcDNA:LP07986; CG18315; Dmel\CG18315
Summary
Predicted to enable AMP binding activity; adenine binding activity; and adenine phosphoribosyltransferase activity. Predicted to be involved in AMP salvage and adenine salvage. Predicted to be active in cytoplasm. Used to study Lesch-Nyhan syndrome. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Aprt in Genome Data Viewer
Location:
62B9-62B9; 3-1.0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1883795..1885019, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1883795..1885019, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dre4 Neighboring gene uncharacterized protein Neighboring gene Tetraspan membrane protein in hair cell stereocilia Neighboring gene debris buster

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species. Johnson D, et al. Mol Cell Biol, 1989 May. PMID 2501662, Free PMC Article
  2. Cloning of a Drosophila melanogaster adenine phosphoribosyltransferase structural gene and deduced amino acid sequence of the enzyme. Johnson DH, et al. Gene, 1987. PMID 3125085
  3. Adenine phosphoribosyltransferase genes in two Drosophila species: dosage compensation, a nuclear matrix attachment site, and a novel intron position. Johnson DH. Mol Gen Genet, 1993 Apr. PMID 8492806
  4. Purine resistant mutants of Drosophila are adenine phosphoribosyltransferase deficient. Johnson DH, et al. Science, 1981 May 29. PMID 17779974
  5. Purine-resistant Drosophila melanogaster result from mutations in the adenine phosphoribosyltransferase structural gene. Johnson DH, et al. Proc Natl Acad Sci U S A, 1983 May. PMID 6407004, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenine salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenine salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenine phosphoribosyltransferase
Names
Aprt-PA
Aprt-PC
Aprt-PD
CG18315-PA
CG18315-PC
CG18315-PD
NP_001286908.1
NP_001286909.1
NP_476637.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1883795..1885019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299979.1 → NP_001286908.1  adenine phosphoribosyltransferase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12426, Q9W069
    UniProtKB/TrEMBL
    X2J8L3
    Conserved Domains (1) summary
    PRK02304
    Location:9 → 182
    PRK02304; adenine phosphoribosyltransferase; Provisional

  2. NM_001299980.1 → NP_001286909.1  adenine phosphoribosyltransferase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286909.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12426, Q9W069
    UniProtKB/TrEMBL
    X2J8L3
    Conserved Domains (1) summary
    PRK02304
    Location:9 → 182
    PRK02304; adenine phosphoribosyltransferase; Provisional

  3. NM_057289.3 → NP_476637.1  adenine phosphoribosyltransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476637.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12426, Q9W069
    UniProtKB/TrEMBL
    X2J8L3
    Related
    FBpp0088438
    Conserved Domains (1) summary
    PRK02304
    Location:9 → 182
    PRK02304; adenine phosphoribosyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12426.3 P12426
X2J8L3 X2J8L3

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