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Su(z)12 Su(z)12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48071, updated on 9-Dec-2024

Summary

Official Symbol
Su(z)12provided by FlyBase
Official Full Name
Su(z)12provided by FlyBase
Primary source
FLYBASE:FBgn0020887
Locus tag
Dmel_CG8013
See related
AllianceGenome:FB:FBgn0020887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8013; Dmel\CG8013; l(3)76BDo; Su(z); su(z)12; Su(Z)12; SU(Z)12; Su(z)[12]; Suz(12); Suz12; SUZ12
Summary
Contributes to nucleosome binding activity. Involved in negative regulation of response to gamma radiation and neurogenesis. Located in nucleus. Part of ESC/E(Z) complex. Is expressed in organism. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Su(z)12 in Genome Data Viewer
Location:
76D4-76D4; 3-46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19918242..19923462, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19911342..19916562, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Precursor RNA processing 3 Neighboring gene Mtr3 Neighboring gene Regulatory particle non-ATPase 1 Neighboring gene Prefoldin 6 Neighboring gene Grasp65

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RSC-type complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin NAS
Non-traceable Author Statement
more info
PubMed 
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Su(z)12
Names
CG8013-PA
CG8013-PB
Su(z)12-PA
Su(z)12-PB
Suppressor-of-zeste-12
suppressor of zeste 12
suppressor of zeste[12]

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19918242..19923462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168826.2NP_730465.1  Su(z)12, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730465.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T9D8, Q9NJG9, Q9VW55
    Related
    FBpp0074686
    Conserved Domains (1) summary
    pfam09733
    Location:511644
    VEFS-Box; VEFS-Box of polycomb protein
  2. NM_143802.3NP_652059.1  Su(z)12, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652059.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NJG9
    Related
    FBpp0074685
    Conserved Domains (1) summary
    pfam09733
    Location:511644
    VEFS-Box; VEFS-Box of polycomb protein