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Nmdmc NAD-dependent methylenetetrahydrofolate dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47895, updated on 9-Dec-2024

Summary

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Official Symbol
Nmdmcprovided by FlyBase
Official Full Name
NAD-dependent methylenetetrahydrofolate dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0010222
Locus tag
Dmel_CG18466
See related
AllianceGenome:FB:FBgn0010222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
151767_at; CG18466; Dmdmc; Dmel\CG18466; dNMDMC; Dnmdmc; DNMDMC; Mthfd2; nmdmc
Summary
Predicted to enable several functions, including magnesium ion binding activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Is expressed in adult head; amnioserosa; embryonic rectum; rectum primordium; and yolk nucleus. Orthologous to several human genes including MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nmdmc in Genome Data Viewer
Location:
85C3-85C3; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9042508..9050555, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4868230..4876277, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR31429 Neighboring gene neuralized Neighboring gene hyrax Neighboring gene Relish Neighboring gene Mst85C Neighboring gene Lysine demethylase 2 Neighboring gene beag Neighboring gene Adenosine deaminase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is targeted to the cytoplasm in insect cell lines. Tremblay GB, et al. FEBS Lett, 1995 Jul 10. PMID 7615077
  2. The Drosophila neuralized gene encodes a C3HC4 zinc finger. Price BD, et al. EMBO J, 1993 Jun. PMID 8508767, Free PMC Article
  3. Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin. Garrido-Maraver J, et al. Cell Death Dis, 2019 Mar 25. PMID 30911005, Free PMC Article
  4. Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species. Yu S, et al. Biochem Biophys Res Commun, 2015 Oct 2. PMID 26319556
  5. The isolation and characterization of a Drosophila gene encoding a putative NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase. Price BD, et al. Biochim Biophys Acta, 1993 Apr 29. PMID 8485162

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables methenyltetrahydrofolate cyclohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methenyltetrahydrofolate cyclohydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphate ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NAD-dependent methylenetetrahydrofolate dehydrogenase
Names
CG18466-PA
CG18466-PB
CG18466-PC
NAD dependent methylenetetrahydrofolate dehydrogenase
Nmdmc-PA
Nmdmc-PB
Nmdmc-PC
NP_001262398.1
NP_476929.1
NP_476930.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9042508..9050555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057581.5 → NP_476929.1  NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476929.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q04448, Q7KSU1, Q9U6H6, Q9V3H4
    Related
    FBpp0081476
    Conserved Domains (3) summary
    COG0190
    Location:9 → 304
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:10 → 126
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    pfam02882
    Location:129 → 303
    THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

  2. NM_057582.5 → NP_476930.1  NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476930.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFE5
    Related
    FBpp0081477
    Conserved Domains (3) summary
    COG0190
    Location:3 → 298
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:4 → 120
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    pfam02882
    Location:123 → 297
    THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

  3. NM_001275469.1 → NP_001262398.1  NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262398.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFE5
    Conserved Domains (3) summary
    COG0190
    Location:3 → 298
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:4 → 120
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    pfam02882
    Location:123 → 297
    THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFE5 A0A0B4KFE5
Q04448.2 Q04448

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