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Amy-p Amylase proximal [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47764, updated on 9-Dec-2024

Summary

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Official Symbol
Amy-pprovided by FlyBase
Official Full Name
Amylase proximalprovided by FlyBase
Primary source
FLYBASE:FBgn0000079
Locus tag
Dmel_CG18730
See related
AllianceGenome:FB:FBgn0000079
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alpha-Amy; alpha-AMY; amy; Amy; AMY; Amy(p); amy-p; Amy-P; Amy-proximal; Amy1; Amy2; Amy4; Amy5; AmyA; AmyD; Amyn.sp; CG18640; CG18730; Dmel\CG18730
Summary
Enables alpha-amylase activity and calcium ion binding activity. Involved in carbohydrate catabolic process. Located in extracellular region. Is expressed in embryonic central brain neurons; embryonic/larval tracheal section; ganglia; lateral cord neurons; and midgut. Orthologous to human AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Amy-p in Genome Data Viewer
Location:
53F11-53F12; 2-81 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17118636..17120303, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13006141..13007808, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45272 Neighboring gene Serpin 53F Neighboring gene Amylase distal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and Functional Characterization of Drosophila melanogaster α-Amylase. Rhimi M, et al. Molecules, 2023 Jul 11. PMID 37513201, Free PMC Article
  2. Enzymatic characterization of recombinant α-amylase in the Drosophila melanogaster species subgroup: is there an effect of specialization on digestive enzyme? Commin C, et al. Genes Genet Syst, 2013. PMID 24463528
  3. Naturally occurring variation in the restriction map of the amy region of Drosophila melanogaster. Langley CH, et al. Genetics, 1988 Jul. PMID 17246437, Free PMC Article
  4. A Drosophila gene promoter is subject to glucose repression in yeast cells. Hickey DA, et al. Proc Natl Acad Sci U S A, 1994 Nov 8. PMID 7526389, Free PMC Article
  5. A molecular explanation of frequency-dependent selection in Drosophila. Haj-Ahmad Y, et al. Nature, 1982 Sep 23. PMID 6180326

See all (165) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-amylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-amylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-amylase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-amylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding TAS
Traceable Author Statement
more info
 PubMed 
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
amylase proximal
Names
Amy-p-PA
Amy-p-PB
Amylase-A
CG18730-PA
CG18730-PB
alpha-amylase
alpha-amylase proximal
amylase
NP_001286518.1
NP_536346.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17118636..17120303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299589.1 → NP_001286518.1  amylase proximal, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286518.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P81641, Q27578, Q27581, Q27585, Q27882, Q27885, Q27897, Q8WP56, Q95NK4, Q969D1, Q9BH39, Q9BH72, Q9BPS5, Q9BPS6, Q9BPS7, Q9BPS8, Q9BPT0, Q9BPT1, Q9BPT2, Q9BPT3, Q9V7Z0
    UniProtKB/TrEMBL
    A0A0B4LGS0
    Conserved Domains (3) summary
    cd11317
    Location:28 → 399
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:405 → 493
    Aamy_C; Aamy_C domain
    pfam00128
    Location:54 → 342
    Alpha-amylase; Alpha amylase, catalytic domain

  2. NM_080421.4 → NP_536346.1  amylase proximal, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_536346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P81641, Q27578, Q27581, Q27585, Q27882, Q27885, Q27897, Q8WP56, Q95NK4, Q969D1, Q9BH39, Q9BH72, Q9BPS5, Q9BPS6, Q9BPS7, Q9BPS8, Q9BPT0, Q9BPT1, Q9BPT2, Q9BPT3, Q9V7Z0
    UniProtKB/TrEMBL
    A0A0B4LGS0
    Related
    FBpp0086155
    Conserved Domains (3) summary
    cd11317
    Location:28 → 399
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:405 → 493
    Aamy_C; Aamy_C domain
    pfam00128
    Location:54 → 342
    Alpha-amylase; Alpha amylase, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGS0 A0A0B4LGS0
P08144.1 P08144
Q2VYA0 Q2VYA0
Q2VYA1 Q2VYA1
Q2VYA3 Q2VYA3

Gene LinkOut

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