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Abd-B - Abdominal B

Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including genital disc development; male pigmentation; and reproductive structure development. Located in nucleus and polytene chromosome band. Is expressed in several structures, including adult posterior abdominal ganglion neurons; anterior-posterior subdivision of organism; epithelium; genital disc; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in congenital vertical talus and radioulnar synostosis. Orthologous to several human genes including HOXA10 (homeobox A10) and HOXC10 (homeobox C10). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa