dmrta2 DMRT-like family A2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dmrta2provided by ZNC
Official Full Name: DMRT-like family A2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041116-2
See related: Ensembl:ENSDARG00000039412 AllianceGenome:ZFIN:ZDB-GENE-041116-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Dmrt5
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within corticotropin hormone secreting cell differentiation and telencephalon development. Predicted to be active in nucleus. Is expressed in central nervous system; ectoderm; endocrine system; and neural keel. Orthologous to human DMRTA2 (DMRT like family A2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (16257220..16259063, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (16221508..16223351, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study establishes a novel function for dmrt5 for cell differentiation in the anterior pituitary.
Title: Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary.
A functional analysis of dmrta2 in Danio rerio is reported; mutagenic analysis suggested that Dmrta2 might regulate the expression of cdkn2c during spermatogenesis.
Title: Zebrafish dmrta2 regulates the expression of cdkn2c in spermatogenesis in the adult testis.
zebrafish Dmrta2 controls neurogenin1 expression by repressing her6 in the posterior-dorsal telencephalon.
Title: Zebrafish Dmrta2 regulates neurogenesis in the telencephalon.
zebrafish Dmrt5 have potentially important roles in gonadal development and may have contributed to the functional endocrine axis
Title: Molecular cloning, characterization, and expression in brain and gonad of Dmrt5 of zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within corticotropin hormone secreting cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within telencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor A2

Names: doublesex and mab-3 related transcription factor like family A2; doublesex- and mab-3-related transcription factor 5; doublesex-like protein Dmrt4a; doublesex-like protein Dmrt4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007064.2 → NP_001007065.2 doublesex- and mab-3-related transcription factor A2

Status: VALIDATED

Source sequence(s)

CU467870

UniProtKB/Swiss-Prot

Q5UU75

UniProtKB/TrEMBL

A0A8M1N301, B8JLF1

Related

ENSDARP00000057589.4, ENSDART00000057590.5

Conserved Domains (2) summary

cd14418
Location:259 → 300

CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)

pfam00751
Location:55 → 101

DM; DM DNA binding domain