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SEPTIN2 septin 2 [ Homo sapiens (human) ]

Gene ID: 4735, updated on 27-Nov-2024

Summary

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Official Symbol
SEPTIN2provided by HGNC
Official Full Name
septin 2provided by HGNC
Primary source
HGNC:HGNC:7729
See related
Ensembl:ENSG00000168385 MIM:601506; AllianceGenome:HGNC:7729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIFF6; NEDD5; SEPT2; NEDD-5; Pnutl3; hNedd5; Septin-2
Summary
Enables identical protein binding activity. Predicted to be involved in several processes, including cilium assembly; regulation of exocytosis; and smoothened signaling pathway. Predicted to act upstream of or within regulation of L-glutamate import across plasma membrane and regulation of protein localization. Located in several cellular components, including cytoskeleton; photoreceptor connecting cilium; and sperm annulus. Part of septin complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in fat (RPKM 77.8), thyroid (RPKM 76.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SEPTIN2 in Genome Data Viewer
Location:
2q37.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241315355..241354027)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241814341..241852889)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242254770..242293442)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene anoctamin 7 Neighboring gene uncharacterized LOC105376810 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242175313-242175524 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242189957-242190163 Neighboring gene high density lipoprotein binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242220649-242221149 Neighboring gene HDLBP antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242248819-242249320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17424 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242255088-242255812 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242255813-242256537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12537 Neighboring gene uncharacterized LOC105373973 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene Sharpr-MPRA regulatory region 5168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242386413-242387062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242407765-242408327 Neighboring gene microRNA 3133

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. Mori T, et al. Cytogenet Cell Genet, 1996. PMID 8697812
  2. Coupling function of cyclin-dependent kinase 2 and Septin2 in the promotion of hepatocellular carcinoma. Xu C, et al. Cancer Sci, 2019 Feb. PMID 30444001, Free PMC Article
  3. Functional Redundancy of Septin Homologs in Dendritic Branching. Kaplan C, et al. Front Cell Dev Biol, 2017. PMID 28265560, Free PMC Article
  4. Septin Mutations in Human Cancers. Angelis D, et al. Front Cell Dev Biol, 2016. PMID 27882315, Free PMC Article
  5. Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers. Kim J, et al. Arterioscler Thromb Vasc Biol, 2021 Jan. PMID 33147991, Free PMC Article

See all (190) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ_0057558 accelerates the development of prostate cancer through miR-1238-3p/SEPT2 axis.
    Title: Circ_0057558 accelerates the development of prostate cancer through miR-1238-3p/SEPT2 axis.
  2. ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion.
    Title: ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion.
  3. An atomic model for the human septin hexamer by cryo-EM.
    Title: An atomic model for the human septin hexamer by cryo-EM.
  4. The LncRNA FGD5-AS1/miR-497-5p axis regulates septin 2 (SEPT2) to accelerate cancer progression and increase cisplatin-resistance in laryngeal squamous cell carcinoma.
    Title: The LncRNA FGD5-AS1/miR-497-5p axis regulates septin 2 (SEPT2) to accelerate cancer progression and increase cisplatin-resistance in laryngeal squamous cell carcinoma.
  5. Orientational Ambiguity in Septin Coiled Coils and its Structural Basis.
    Title: Orientational Ambiguity in Septin Coiled Coils and its Structural Basis.
  6. MicroRNA7445p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype.
    Title: MicroRNA‑744‑5p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype.
  7. Molecular Recognition at Septin Interfaces: The Switches Hold the Key.
    Title: Molecular Recognition at Septin Interfaces: The Switches Hold the Key.
  8. Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers.
    Title: Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers.
  9. The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer.
    Title: The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer.
  10. Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.
    Title: Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0158

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm annulus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
septin-2
Names
epididymis secretory sperm binding protein
neural precursor cell expressed, developmentally down-regulated 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008491.3 → NP_001008491.1  septin-2 isoform a

    See identical proteins and their annotated locations for NP_001008491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    AA482233, BC014455, BX648000, D63878
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Related
    ENSP00000353157.3, ENST00000360051.7
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  2. NM_001008492.3 → NP_001008492.1  septin-2 isoform a

    See identical proteins and their annotated locations for NP_001008492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    AA482233, BX648000, D63878, DB091579
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Related
    ENSP00000385172.2, ENST00000402092.6
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  3. NM_001282972.2 → NP_001269901.1  septin-2 isoform b

    See identical proteins and their annotated locations for NP_001269901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AA482233, AK294563, BX648000, D63878, DB091579
    Consensus CDS
    CCDS74682.1
    UniProtKB/Swiss-Prot
    Q15019
    Related
    ENSP00000479861.1, ENST00000616972.4
    Conserved Domains (2) summary
    COG5019
    Location:50 → 369
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00735
    Location:69 → 341
    Septin; Septin

  4. NM_001282973.2 → NP_001269902.1  septin-2 isoform c

    See identical proteins and their annotated locations for NP_001269902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is longer than isoform a. Variants 6 and 15 encode the same isoform (c).
    Source sequence(s)
    AA482233, BC014455, BC033559, BX648000
    Consensus CDS
    CCDS63195.1
    UniProtKB/TrEMBL
    A0A384N6H6
    Related
    ENSP00000385109.1, ENST00000401990.5
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 316
    Septin; Septin

  5. NM_001321029.2 → NP_001307958.1  septin-2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    BC033559, BX648000, D63878, R38654
    UniProtKB/Swiss-Prot
    Q15019
    Conserved Domains (2) summary
    COG5019
    Location:45 → 362
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00735
    Location:64 → 336
    Septin; Septin

  6. NM_001321030.3 → NP_001307959.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    BX648000, D63878, DA544741, DB224668, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  7. NM_001321031.2 → NP_001307960.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    BX648000, D63878, DA444624, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  8. NM_001321032.2 → NP_001307961.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    BX648000, CN282754, D63878, DB091579, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  9. NM_001321033.3 → NP_001307962.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    AC104841, BX648000, D63878, DB224668, HY043466, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  10. NM_001321034.2 → NP_001307963.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    BX648000, D63878, DB091579, DB277926, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  11. NM_001321035.2 → NP_001307964.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    BX648000, CN282712, D63878, DB091579, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  12. NM_001349287.2 → NP_001336216.1  septin-2 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC005104, AC104841, R38654
    Conserved Domains (1) summary
    pfam00735
    Location:90 → 361
    Septin

  13. NM_001349288.2 → NP_001336217.1  septin-2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR and contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (c) is longer than isoform a. Variants 6 and 15 encode the same isoform (c).
    Source sequence(s)
    AC005104, AC104841, R38654
    Consensus CDS
    CCDS63195.1
    UniProtKB/TrEMBL
    A0A384N6H6
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 316
    Septin; Septin

  14. NM_001349289.2 → NP_001336218.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    AC005104, AC104841, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  15. NM_001349290.2 → NP_001336219.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    AC005104, AC104841, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  16. NM_001349291.2 → NP_001336220.1  septin-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    AC005104, AC104841, R38654
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  17. NM_001349302.2 → NP_001336231.1  septin-2 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (f) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC005104, AC104841, R38654
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 303
    Septin

  18. NM_001349304.2 → NP_001336233.1  septin-2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (g) has a shorter N-terminus compared to isoform a. Variants 20-22 encode the same isoform (g).
    Source sequence(s)
    AC005104, AC104841, R38654
    Consensus CDS
    CCDS86930.1
    UniProtKB/TrEMBL
    B5MCX3
    Related
    ENSP00000384525.1, ENST00000407971.5
    Conserved Domains (1) summary
    pfam00735
    Location:1 → 266
    Septin

  19. NM_001349305.2 → NP_001336234.1  septin-2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (g) has a shorter N-terminus compared to isoform a. Variants 20-22 encode the same isoform (g).
    Source sequence(s)
    AC005104, AC104841, R38654
    Consensus CDS
    CCDS86930.1
    UniProtKB/TrEMBL
    B5MCX3
    Conserved Domains (1) summary
    pfam00735
    Location:1 → 266
    Septin

  20. NM_001349306.2 → NP_001336235.1  septin-2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (g) has a shorter N-terminus compared to isoform a. Variants 20-22 encode the same isoform (g).
    Source sequence(s)
    AC005104, AC104841, R38654
    Consensus CDS
    CCDS86930.1
    UniProtKB/TrEMBL
    B5MCX3
    Conserved Domains (1) summary
    pfam00735
    Location:1 → 266
    Septin

  21. NM_001349307.2 → NP_001336236.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  22. NM_001349308.2 → NP_001336237.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  23. NM_001349309.2 → NP_001336238.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  24. NM_001349310.2 → NP_001336239.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  25. NM_001349311.2 → NP_001336240.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  26. NM_001349312.2 → NP_001336241.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  27. NM_001349313.2 → NP_001336242.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  28. NM_001349314.2 → NP_001336243.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (30) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  29. NM_001349315.2 → NP_001336244.1  septin-2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
    Source sequence(s)
    AC005104, AC104841, R38654
    UniProtKB/TrEMBL
    H7C2Y0
    Conserved Domains (1) summary
    cl40481
    Location:1 → 139
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  30. NM_004404.5 → NP_004395.1  septin-2 isoform a

    See identical proteins and their annotated locations for NP_004395.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    AA482233, AF038404, BX648000, DB091579
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Related
    ENSP00000375832.2, ENST00000391971.7
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  31. NM_006155.3 → NP_006146.1  septin-2 isoform a

    See identical proteins and their annotated locations for NP_006146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
    Source sequence(s)
    AA482233, BX648000, D63878, DB035463, DB095611
    Consensus CDS
    CCDS2548.1
    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Related
    ENSP00000375834.2, ENST00000391973.6
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    241315355..241354027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452921.2 → XP_024308689.1  septin-2 isoform X1

    Conserved Domains (1) summary
    pfam00735
    Location:102 → 373
    Septin; Septin

  2. XM_024452920.2 → XP_024308688.1  septin-2 isoform X1

    Conserved Domains (1) summary
    pfam00735
    Location:102 → 373
    Septin; Septin

  3. XM_047444494.1 → XP_047300450.1  septin-2 isoform X2

  4. XM_047444495.1 → XP_047300451.1  septin-2 isoform X3

  5. XM_047444499.1 → XP_047300455.1  septin-2 isoform X4

    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

  6. XM_047444492.1 → XP_047300448.1  septin-2 isoform X1

  7. XM_024452922.2 → XP_024308690.1  septin-2 isoform X2

    Conserved Domains (1) summary
    pfam00735
    Location:97 → 368
    Septin

  8. XM_047444496.1 → XP_047300452.1  septin-2 isoform X3

  9. XM_047444498.1 → XP_047300454.1  septin-2 isoform X4

    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

  10. XM_024452925.2 → XP_024308693.1  septin-2 isoform X4

    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
    Conserved Domains (1) summary
    pfam00735
    Location:35 → 306
    Septin

  11. XM_047444493.1 → XP_047300449.1  septin-2 isoform X1

  12. XM_047444500.1 → XP_047300456.1  septin-2 isoform X5

  13. XM_047444497.1 → XP_047300453.1  septin-2 isoform X4

    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

  14. XM_047444501.1 → XP_047300457.1  septin-2 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    241814341..241852889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342260.1 → XP_054198235.1  septin-2 isoform X1

  2. XM_054342259.1 → XP_054198234.1  septin-2 isoform X1

  3. XM_054342263.1 → XP_054198238.1  septin-2 isoform X2

  4. XM_054342265.1 → XP_054198240.1  septin-2 isoform X3

  5. XM_054342270.1 → XP_054198245.1  septin-2 isoform X4

    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

  6. XM_054342261.1 → XP_054198236.1  septin-2 isoform X1

  7. XM_054342264.1 → XP_054198239.1  septin-2 isoform X2

  8. XM_054342266.1 → XP_054198241.1  septin-2 isoform X3

  9. XM_054342269.1 → XP_054198244.1  septin-2 isoform X4

    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

  10. XM_054342267.1 → XP_054198242.1  septin-2 isoform X4

    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

  11. XM_054342262.1 → XP_054198237.1  septin-2 isoform X1

  12. XM_054342271.1 → XP_054198246.1  septin-2 isoform X5

  13. XM_054342268.1 → XP_054198243.1  septin-2 isoform X4

    UniProtKB/Swiss-Prot
    B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

  14. XM_054342272.1 → XP_054198247.1  septin-2 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15019.1 GenPept UniProtKB/Swiss-Prot:Q15019

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