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peo pendolino [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47272, updated on 9-Dec-2024

Summary

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Official Symbol
peoprovided by FlyBase
Official Full Name
pendolinoprovided by FlyBase
Primary source
FLYBASE:FBgn0288856
Locus tag
Dmel_CG46338
See related
AllianceGenome:FB:FBgn0288856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cbx; CG10536; CG46338; Dmel\CG46338; Ft1; pen
Summary
Involved in defense response to bacterium and sperm individualization. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See peo in Genome Data Viewer
Location:
46B4-46C1; 2-61 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9864510..9875072, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5752015..5762577, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pyruvate carboxylase Neighboring gene antisense RNA:CR44293 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45138 Neighboring gene N-terminal methyltransferase Neighboring gene Linking immunity and metabolism Neighboring gene uncharacterized protein Neighboring gene Secretory 24AB Neighboring gene antisense RNA:CR45467 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Interplay Between Developmental Stage and Environment Underlies the Adaptive Effect of a Natural Transposable Element Insertion. Merenciano M, et al. Mol Biol Evol, 2023 Mar 4. PMID 36811953, Free PMC Article
  2. Lime is a new protein linking immunity and metabolism in Drosophila. Mihajlovic Z, et al. Dev Biol, 2019 Aug 15. PMID 31085193
  3. Genetic dissection of sperm individualization in Drosophila melanogaster. Fabrizio JJ, et al. Development, 1998 May. PMID 9550716
  4. The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres. Cenci G, et al. PLoS Genet, 2015 Jun. PMID 26110638, Free PMC Article
  5. Low dose rate γ-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious. Porrazzo A, et al. Commun Biol, 2022 Sep 3. PMID 36057690, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c9870307-9870102 mobile_element_type = transposon:S{}792
  • Loc: c9870658-9870308 mobile_element_type = transposon:rooA{}3681
  • Loc: c9874665-9874431 mobile_element_type = transposon:INE-1{}3636

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables ubiquitin conjugating enzyme activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
pendolino
Names
CG46338-PA
CG46338-PB
CG46338-PC
peo-PA
peo-PB
peo-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9864510..9875072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165716.2 → NP_724848.1  pendolino, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724848.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K4V4
    Related
    FBpp0422655
    Conserved Domains (1) summary
    cl00154
    Location:6 → 139
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_001273908.1 → NP_001260837.1  pendolino, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260837.1

    Status: REVIEWED

    Conserved Domains (1) summary
    cl00154
    Location:6 → 99
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_080149.4 → NP_524888.1  pendolino, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524888.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KF51, Q7JRK3, Q7K4V4
    Related
    FBpp0422656
    Conserved Domains (2) summary
    COG5078
    Location:24 → 176
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cl00154
    Location:19 → 169
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF51 A0A0B4KF51
Q7K4V4.1 Q7K4V4

Gene LinkOut

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