PolZ1 DNA polymerase zeta subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PolZ1provided by FlyBase
Official Full Name: DNA polymerase zeta subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0002891
Locus tag: Dmel_CG1925
See related: AllianceGenome:FB:FBgn0002891
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 154926_at; AAF59191; CG1925; DhRev3; Dmel\CG1925; Dmpolzeta; DmREV3; DNApol-zeta; mus 205; mus(2)205; mus-205; mus205; Mus205; rev3; Rev3
Summary: Enables DNA-directed DNA polymerase activity. Involved in DNA synthesis involved in double-strand break repair via homologous recombination. Part of zeta DNA polymerase complex. Is expressed in spermatozoon and wing disc. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7793625..7801044)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3681130..3688549)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables 3'-5' exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA synthesis involved in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA synthesis involved in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in error-prone translesion synthesis	IDA Inferred from Direct Assay more info	PubMed
involved_in translesion synthesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of zeta DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of zeta DNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of zeta DNA polymerase complex	IPI Inferred from Physical Interaction more info	PubMed

Names: CG1925-PA; DNA polymerase zeta catalytic subunit; PolZ1-PA; mutagen-sensitive 205

NP_524881.2

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