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arg arginase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46717, updated on 4-Jan-2025

Summary

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Official Symbol
argprovided by FlyBase
Official Full Name
arginaseprovided by FlyBase
Primary source
FLYBASE:FBgn0023535
Locus tag
Dmel_CG18104
See related
AllianceGenome:FB:FBgn0023535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Arg; CG18104; Dmel\CG18104; EG:171D11.4; EG:65F1.3
Summary
Predicted to enable arginase activity and manganese ion binding activity. Predicted to be involved in arginine catabolic process to ornithine. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol. Is expressed in embryonic/larval fat body; head; and organism. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1) and ARG2 (arginase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See arg in Genome Data Viewer
Location:
1B7-1B8; 1-0 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (509435..528028)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (403468..422061)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44891 Neighboring gene antisense RNA:CR44892 Neighboring gene silver Neighboring gene elav noncoding regulatory RNA Neighboring gene embryonic lethal abnormal vision Neighboring gene uncharacterized protein Neighboring gene beta amyloid protein precursor-like Neighboring gene mir-4960 stem loop Neighboring gene ventral nervous system defective Neighboring gene split discs

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila arginase is produced from a nonvital gene that contains the elav locus within its third intron. Samson ML. J Biol Chem, 2000 Oct 6. PMID 10878001
  2. Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation in vivo. Immarigeon C, et al. J Biol Chem, 2020 Sep 25. PMID 32737196, Free PMC Article
  3. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564
  4. GeneFizz: A web tool to compare genetic (coding/non-coding) and physical (helix/coil) segmentations of DNA sequences. Gene discovery and evolutionary perspectives. Yeramian E, et al. Nucleic Acids Res, 2003 Jul 1. PMID 12824434, Free PMC Article
  5. Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer. Lusk JB, et al. Cancers (Basel), 2017 Feb 7. PMID 28178204, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables arginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginine catabolic process to ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine catabolic process to ornithine ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in arginine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
arginase
Names
CG18104-PA
arg-PA
NP_524875.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    509435..528028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080136.3 → NP_524875.1  arginase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524875.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76895, Q9NHA5
    Related
    FBpp0070083
    Conserved Domains (1) summary
    cd09989
    Location:32 → 331
    Arginase; Arginase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76895 O76895
Q9NHA5 Q9NHA5
Q9W5F2 Q9W5F2

Gene LinkOut

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