CanB2 Calcineurin B2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CanB2provided by FlyBase
Official Full Name: Calcineurin B2provided by FlyBase
Primary source: FLYBASE:FBgn0015614
Locus tag: Dmel_CG11217
See related: AllianceGenome:FB:FBgn0015614
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CaN; canB2; CaNB2; CG11217; CS2-1; dCnB2; dCNB2; Dmel\CG11217
Summary: Predicted to enable several functions, including calcium ion binding activity; calcium-dependent protein serine/threonine phosphatase regulator activity; and calmodulin binding activity. Involved in meiotic cell cycle; sarcomere organization; and sleep. Predicted to be part of calcineurin complex. Is expressed in several structures, including adult brain; adult optic lobe; embryonic/larval midgut primordium; gut section; and larval muscle system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to several human genes including PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7786010..7789053)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3673515..3676558)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

results indicate a role for Cn and calcium-dependent signal transduction in sleep and memory regulation.
Title: Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster.
CanB2 has a role in flight muscle formation in Drosophila
Title: Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in synaptic vesicle	NAS Non-traceable Author Statement more info	PubMed

Names: CG11217-PA; CG11217-PB; CanB2-PA; CanB2-PB; calcineurin suppressor, chromosome 2, group 1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain