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CG11899 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46391, updated on 9-Dec-2024

Summary

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Official Symbol
CG11899provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0014427
Locus tag
Dmel_CG11899
See related
AllianceGenome:FB:FBgn0014427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
39C10S; anon-sts29; Dmel\CG11899; ESTS:39C10S; Ov8
Summary
Predicted to enable O-phospho-L-serine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG11899 in Genome Data Viewer
Location:
99A1-99A1; 3-98 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29200454..29201770)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25026176..25027492)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene julius seizure Neighboring gene uncharacterized protein Neighboring gene Cytochrome c1-like Neighboring gene Metazoan SpoT homolog-1 Neighboring gene long non-coding RNA::CR31044 Neighboring gene mir-279 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila. Wang R, et al. Nat Commun, 2022 Jun 20. PMID 35725845, Free PMC Article
  2. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Sun D, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818390
  3. A Drosophila model of Friedreich ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-acetyl cysteine. Russi M, et al. Hum Mol Genet, 2020 Oct 10. PMID 32744307
  4. Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60. Schirling C, et al. Chromosoma, 2010 Feb. PMID 19949809
  5. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-serine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-serine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11899-PA
NP_652046.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29200454..29201770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143789.3 → NP_652046.1  uncharacterized protein Dmel_CG11899 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652046.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3YMT6, Q9VAN0
    Related
    FBpp0084759
    Conserved Domains (1) summary
    cd00611
    Location:3 → 360
    PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAN0.1 Q9VAN0

Gene LinkOut

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