ND-SGDH NADH dehydrogenase (ubiquinone) SGDH subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ND-SGDHprovided by FlyBase
Official Full Name: NADH dehydrogenase (ubiquinone) SGDH subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0011455
Locus tag: Dmel_CG9762
See related: AllianceGenome:FB:FBgn0011455
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9762; Dmel\CG9762; dND-SGDH; dNDUFB5; l(3)neo18; NDUFB5; NISM; Q9VTU2
Summary: Involved in determination of adult lifespan and response to reactive oxygen species. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and larval somatic muscle cell. Orthologous to human NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12137496..12138584, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12130596..12131684, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrion	HDA more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

Names: CG9762-PA; CG9762-PB; NADH ubiquinone oxidoreductase SGDH; NADH-ubiquinone oxidoreductase SGDH subunit; NADH:ubiquinone oxidoreductase SGDH subunit; ND-SGDH-PA; ND-SGDH-PB; lethal (3) neo18

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The following sections contain reference sequences that belong to a specific genome build. Explain