scw screw [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: scwprovided by FlyBase
Official Full Name: screwprovided by FlyBase
Primary source: FLYBASE:FBgn0005590
Locus tag: Dmel_CG31695
See related: AllianceGenome:FB:FBgn0005590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD30945; CG31695; Dmel\CG31695; DmSCW; l(2)37Ff; l(2)IG76; mor2; Scw; SCW
Summary: Enables protein heterodimerization activity and receptor ligand activity. Involved in several processes, including BMP signaling pathway; amnioserosa formation; and digestive tract mesoderm development. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; central brain anlage; central brain anlage in statu nascendi; and dorsal ectoderm anlage. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including BMP5 (bone morphogenetic protein 5); BMP7 (bone morphogenetic protein 7); and BMP8A (bone morphogenetic protein 8a). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19699379..19700968, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19699379..19700968, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

These data reveal novel mechanisms by which post-translational regulation of Scw can modulate Dpp signaling activity.
Title: Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis.
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
Title: Robustness of the BMP morphogen gradient in Drosophila embryonic patterning.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amnioserosa formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	TAS Traceable Author Statement more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain