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retn retained [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45976, updated on 4-Jan-2025

Summary

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Official Symbol
retnprovided by FlyBase
Official Full Name
retainedprovided by FlyBase
Primary source
FLYBASE:FBgn0004795
Locus tag
Dmel_CG5403
See related
AllianceGenome:FB:FBgn0004795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2535; BcDNA:LD35748; CG5403; Dead Ringer/Retain; Dmel\CG5403; dri; Dri; DRI; EHMT; EY2-10; l(2)02535; Retn; retn/dri
Summary
Enables DNA-binding transcription factor binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including neurogenesis; regulation of DNA-templated transcription; and regulation of female receptivity. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; ganglia; gut section; neurohemal organ; and pharyngeal muscle cell. Orthologous to several human genes including ARID3A (AT-rich interaction domain 3A) and ARID3C (AT-rich interaction domain 3C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See retn in Genome Data Viewer
Location:
59F5-59F5; 2-104 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23632610..23654820)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19520133..19542343)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Entomoglyceroporin 2 Neighboring gene Entomoglyceroporin 3 Neighboring gene Entomoglyceroporin 4 Neighboring gene long non-coding RNA:CR45153 Neighboring gene Phosphodiesterase 8 Neighboring gene Sulfotransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Compensating increases in protein backbone flexibility occur when the Dead ringer AT-rich interaction domain (ARID) binds DNA: a nitrogen-15 relaxation study. Iwahara J, et al. Protein Sci, 2005 May. PMID 15802641, Free PMC Article
  2. The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA. Iwahara J, et al. EMBO J, 2002 Mar 1. PMID 11867548, Free PMC Article
  3. Solution structure of the DNA binding domain from Dead ringer, a sequence-specific AT-rich interaction domain (ARID). Iwahara J, et al. EMBO J, 1999 Nov 1. PMID 10545119, Free PMC Article
  4. The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity. Dallas PB, et al. Mol Cell Biol, 2000 May. PMID 10757798, Free PMC Article
  5. Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins. Gregory SL, et al. Mol Cell Biol, 1996 Mar. PMID 8622680, Free PMC Article

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors
    Title: Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors.
  2. RETN has a role in Drosophila preblastoderm syncytial mitoses
    Title: The Drosophila retained/dead ringer gene and ARID gene family function during development.
  3. Dead ringer's preference for AT-rich DNA originates from three positions within the ARID fold that form energetically significant contacts to an adenine-thymine base step.
    Title: The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA.
  4. three genes, dead ringer (dri), Serrate (Ser), and trh itself, are expressed in the embryonic salivary duct independently of trh
    Title: Specification of cell fates within the salivary gland primordium.
  5. Data suggest that Drosphila dead ringer is an important regulator of the late development of longitudinal glia.
    Title: The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in oogenesis HMP PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of female receptivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in salivary gland development NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
retained
Names
CG5403-PA
CG5403-PB
CG5403-PC
CG5403-PD
CG5403-PE
dead Ringer/Retain
dead ringer
dead-ringer
retn-PA
retn-PB
retn-PC
retn-PD
retn-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23632610..23654820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176254.2 → NP_788434.1  retained, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788434.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24573, Q8MSB0, Q9W1M0
    Related
    FBpp0071982
    Conserved Domains (1) summary
    smart00501
    Location:294 → 386
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

  2. NM_057516.4 → NP_476864.2  retained, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476864.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24573
    Related
    FBpp0071981
    Conserved Domains (1) summary
    smart00501
    Location:289 → 381
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

  3. NM_001299846.1 → NP_001286775.1  retained, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286775.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGB3
    Conserved Domains (1) summary
    smart00501
    Location:37 → 129
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

  4. NM_001299844.1 → NP_001286773.1  retained, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286773.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGF9
    Conserved Domains (1) summary
    smart00501
    Location:287 → 379
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

  5. NM_001299845.1 → NP_001286774.1  retained, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286774.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHB8
    Conserved Domains (1) summary
    smart00501
    Location:18 → 110
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGB3 A0A0B4LGB3
A0A0B4LGF9 A0A0B4LGF9
A0A0B4LHB8 A0A0B4LHB8
Q24573.2 Q24573

Gene LinkOut

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