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kkv krotzkopf verkehrt [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45884, updated on 17-Dec-2024

Summary

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Official Symbol
kkvprovided by FlyBase
Official Full Name
krotzkopf verkehrtprovided by FlyBase
Primary source
FLYBASE:FBgn0001311
Locus tag
Dmel_CG2666
See related
AllianceGenome:FB:FBgn0001311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
blimp; Blimp; CG2666; chitin synthase; ChSB; CS-1; CS-1/kkv; DmCS-1; DmeCHS1; DmeChSB; Dmel\CG2666; Kkv; l(3)82Fh
Summary
Enables chitin synthase activity. Involved in several processes, including chitin biosynthetic process; epithelial tube morphogenesis; and respiratory system development. Located in apical plasma membrane and cytoplasm. Is expressed in several structures, including embryonic epipharynx; embryonic hypopharynx; epithelium; gut section; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See kkv in Genome Data Viewer
Location:
83A1-83A1; 3-47.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5378093..5392866, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1203815..1218588, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene 7B2 Neighboring gene transfer RNA:Arginine-TCG 4-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 83a Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of chitin in exoskeleton morphogenesis in Drosophila melanogaster. Moussian B, et al. J Morphol, 2005 Apr. PMID 15747378
  2. Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of action on chitin biosynthesis. Douris V, et al. Proc Natl Acad Sci U S A, 2016 Dec 20. PMID 27930336, Free PMC Article
  3. Fatty acid binding protein is required for chitin biosynthesis in the wing of Drosophila melanogaster. Chen J, et al. Insect Biochem Mol Biol, 2022 Oct. PMID 36165873
  4. SERCA interacts with chitin synthase and participates in cuticular chitin biogenesis in Drosophila. Zhu W, et al. Insect Biochem Mol Biol, 2022 Jun. PMID 35525402
  5. Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development. Duan Y, et al. Insect Biochem Mol Biol, 2022 Feb. PMID 34982980

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
    Title: A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
  2. Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development.
    Title: Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development.
  3. when Kkv and Exp/Reb are co-expressed in the ectoderm, they promote chitin deposition, even in tissues normally devoid of this polysaccharide.
    Title: Deciphering the genetic programme triggering timely and spatially-regulated chitin deposition.
  4. Encodes chitin synthase, maps to Chromosome 3 near the centromere.
    Title: Genetic control of cuticle formation during embryonic development of Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables chitin synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chitin synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based embryonic cuticle biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic epithelial tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liquid clearance, open tracheal system HMP PubMed 
involved_in lumen formation, open tracheal system HMP PubMed 
involved_in lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube diameter, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in trachea morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
krotzkopf verkehrt
Names
CG2666-PA
CG2666-PC
CG2666-PD
chitin Syn1
chitin synthase
chitin synthase 1
chitin synthase B
chitin synthase-1
kkv-PA
kkv-PC
kkv-PD
krotzkopf-verkehrt
short of breath
NP_524233.1
NP_730928.2
NP_996152.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5378093..5392866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169052.3 → NP_730928.2  krotzkopf verkehrt, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730928.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7P4
    Conserved Domains (1) summary
    cd04190
    Location:583 → 904
    Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin

  2. NM_079509.3 → NP_524233.1  krotzkopf verkehrt, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524233.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPN4
    Related
    FBpp0078442
    Conserved Domains (1) summary
    cd04190
    Location:583 → 904
    Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin

  3. NM_206430.3 → NP_996152.1  krotzkopf verkehrt, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996152.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPN4
    Conserved Domains (1) summary
    cd04190
    Location:583 → 904
    Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IPN4 Q8IPN4
Q8MQN8 Q8MQN8
Q8WQ84 Q8WQ84
Q961Q5 Q961Q5
Q9GTZ7 Q9GTZ7
Q9I7P4 Q9I7P4

Gene LinkOut

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