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cpo couch potato [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45840, updated on 4-Jan-2025

Summary

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Official Symbol
cpoprovided by FlyBase
Official Full Name
couch potatoprovided by FlyBase
Primary source
FLYBASE:FBgn0263995
Locus tag
Dmel_CG43738
See related
AllianceGenome:FB:FBgn0263995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1824; 3603; 5339; 6015; BcDNA:AT31405; CG12349; CG18434; cg18435; CG18435; CG31243; CG42457; CG43738; Cpo; CPO; Dmel\CG43738; E(sda)N; l(3)01432; l(3)6015; l(3)j4A1; l(3)j4D4; l(3)j7E2; l(3)j9B3; l(3)rJ553; l(3)s2336; Line N; ORE-17
Old locus tag
Dmel_CG31243; Dmel_CG42457
Summary
Predicted to enable mRNA binding activity. Involved in chemical synaptic transmission; dormancy process; and regulation of hemocyte proliferation. Located in nucleus. Is expressed in several structures, including imaginal disc; midgut; sense organ; sensory nervous system primordium; and sensory neurons. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor) and RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cpo in Genome Data Viewer
Location:
90D1-90E1; 3-61 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17919832..18018892)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13745554..13844614)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rab3 interacting molecule Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Deoxyribonuclease II Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polymorphism in the couch potato gene clines in eastern Australia but is not associated with ovarian dormancy in Drosophila melanogaster. Lee SF, et al. Mol Ecol, 2011 Jul. PMID 21689187
  2. The intensity of selection acting on the couch potato gene--spatial-temporal variation in a diapause cline. Cogni R, et al. Evolution, 2014 Feb. PMID 24303812
  3. Genomic Responses to Climate Change: Making the Most of the Drosophila Model. Rodrigues MF, et al. Front Genet, 2021. PMID 34326859, Free PMC Article
  4. Larval chemosensory projections and invasion of adult afferents in the antennal lobe of Drosophila. Tissot M, et al. J Neurobiol, 1997 Mar. PMID 9058321
  5. An Intronic Polymorphism in couch potato Is Not Distributed Clinally in European Drosophila melanogaster Populations nor Does It Affect Diapause Inducibility. Zonato V, et al. PLoS One, 2016. PMID 27598401, Free PMC Article

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family has been reported
    Title: Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
  2. The results reveal that the downstream cpo SNP does not seem to play any role in diapause induction in European Drosophila populations in contrast to the upstream coding cpo SNP.
    Title: An Intronic Polymorphism in couch potato Is Not Distributed Clinally in European Drosophila melanogaster Populations nor Does It Affect Diapause Inducibility.
  3. There is no evidence for an association between the cpo I462K polymorphism and ovarian dormancy in Australian fruit flies.
    Title: Polymorphism in the couch potato gene clines in eastern Australia but is not associated with ovarian dormancy in Drosophila melanogaster.
  4. variation for the diapause phenotype is caused by a single Lys/Ile substitution in one of the six cpo transcripts
    Title: An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Drosophila melanogaster.
  5. cpo has a role in regulating proper nervous system function, including seizure susceptibility
    Title: Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dormancy process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
couch potato
Names
CG43738-PN
CG43738-PO
CG43738-PP
CG43738-PQ
CG43738-PR
CG43738-PS
CG43738-PT
CG43738-PU
CG43738-PV
CG43738-PW
CG43738-PX
CG43738-PY
couchpotato
cpo-PN
cpo-PO
cpo-PP
cpo-PQ
cpo-PR
cpo-PS
cpo-PT
cpo-PU
cpo-PV
cpo-PW
cpo-PX
cpo-PY
NP_001014631.3
  • non-AUG (CUG) translation initiation
NP_001014632.3
  • non-AUG (CUG) translation initiation
NP_001163640.2
  • non-AUG (CUG) translation initiation
NP_001262688.1
  • non-AUG (CUG) translation initiation
NP_001262689.1
  • non-AUG (CUG) translation initiation
NP_001262690.1
  • non-AUG (CUG) translation initiation
NP_001262691.1
  • non-AUG (CUG) translation initiation
NP_001262692.1
  • non-AUG (CUG) translation initiation
NP_524844.6
  • non-AUG (CUG) translation initiation
NP_732282.6
  • non-AUG (CUG) translation initiation
NP_732283.5
  • non-AUG (CUG) translation initiation
NP_732284.5
  • non-AUG (CUG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17919832..18018892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014631.3 → NP_001014631.3  couch potato, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014631.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01617
    Conserved Domains (2) summary
    COG0724
    Location:428 → 526
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 524
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

  2. NM_169781.4 → NP_732282.6  couch potato, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732282.6

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01617
    Conserved Domains (3) summary
    COG0724
    Location:428 → 526
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 524
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins
    cl17169
    Location:713 → 737
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001170169.3 → NP_001163640.2  couch potato, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163640.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01617
    Conserved Domains (2) summary
    COG0724
    Location:428 → 526
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 524
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

  4. NM_169782.3 → NP_732283.5  couch potato, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732283.5

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
    UniProtKB/TrEMBL
    A0A0B4KGD8
    Conserved Domains (2) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

  5. NM_001275761.1 → NP_001262690.1  couch potato, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262690.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHB6
    Conserved Domains (3) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins
    cl17169
    Location:712 → 734
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. NM_001275762.1 → NP_001262691.1  couch potato, isoform W [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262691.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
    UniProtKB/TrEMBL
    A0A0B4KGD8
    Conserved Domains (2) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

  7. NM_001014632.4 → NP_001014632.3  couch potato, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014632.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01617
    Conserved Domains (3) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12245
    Location:712 → 819
    RRM_scw1_like; RNA recognition motif in yeast cell wall integrity protein scw1 and similar proteins
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

  8. NM_001275759.1 → NP_001262688.1  couch potato, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262688.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGV8
    Conserved Domains (3) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins
    cl17169
    Location:712 → 736
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. NM_001275763.1 → NP_001262692.1  couch potato, isoform X [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262692.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
    UniProtKB/TrEMBL
    A0A0B4KGD8
    Conserved Domains (2) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

  10. NM_080105.4 → NP_524844.6  couch potato, isoform Y [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524844.6

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
    UniProtKB/TrEMBL
    A0A0B4KGD8
    Conserved Domains (2) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

  11. NM_169783.4 → NP_732284.5  couch potato, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732284.5

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
    UniProtKB/TrEMBL
    A0A0B4KGD8
    Conserved Domains (2) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

  12. NM_001275760.1 → NP_001262689.1  couch potato, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHP4
    Conserved Domains (3) summary
    COG0724
    Location:428 → 525
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12684
    Location:441 → 523
    RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins
    cl17169
    Location:712 → 736
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGD8 A0A0B4KGD8
A0A0B4KGV8 A0A0B4KGV8
A0A0B4KHB6 A0A0B4KHB6
A0A0B4KHP4 A0A0B4KHP4
Q01617.4 Q01617

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