bel belle [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: belprovided by FlyBase
Official Full Name: belleprovided by FlyBase
Primary source: FLYBASE:FBgn0263231
Locus tag: Dmel_CG9748
See related: AllianceGenome:FB:FBgn0263231
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-85Ab; Bel; BEL; Belle; BELLE; cap; cg9748; CG9748; DDX3; Dmel\CG9748; DmRH6; l(3)85Ac; l(3)L3; l(3)L4740; l(3)S047110; l(3)S097074; L3; ms(3)neo30; ms(3)Pneo85A; psg9
Summary: Enables RNA helicase activity. Involved in several processes, including autophagic cell death; male germ-line stem cell population maintenance; and response to ecdysone. Located in P granule and neuronal cell body. Part of RISC complex. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval salivary gland; germline cell; and synaptic neuropil domain. Used to study Sertoli cell-only syndrome. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 85A5-85A5; 3-48 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8654975..8660761, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4480697..4486483, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set.
Title: The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set.
Bel is required for nos mRNA translational repression.
Title: Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch.
DDX3/Belle Exerts Its Function Outside of the Wnt/Wingless Signaling Pathway
Title: Drosophila DDX3/Belle Exerts Its Function Outside of the Wnt/Wingless Signaling Pathway.
show that genetic inhibition of Bel function leads to de novo generation of piRNAs from the transgene region inserted in the genome, suggesting a potential piRNA-dependent mechanism that may mediate transgene silencing as Bel function is inhibited
Title: RNA helicase Belle/DDX3 regulates transgene expression in Drosophila.
Results suggest that a role of RNA helicase Belle in germline stem cells (GSCs) and maintenance and germline stem cells (GSCs)regulation of early germ cell divisions.
Title: RNA helicase Belle (DDX3) is essential for male germline stem cell maintenance and division in Drosophila.
findings show that the belle (bel) mRNA is translationally repressed by the d4EHP protein in the Drosophila ovary. Consistent with this regulation, d4EHP overexpression in the ovary phenocopies the bel mutant.
Title: Patterning of the Drosophila oocyte by a sequential translation repression program involving the d4EHP and Belle translational repressors.
DEAD-box RNA helicase Belle and the RNA interference pathway promote mitotic chromosome segregation.
Title: DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation.
Belle might be functioning in the microRNA pathway in follicle cells.
Title: The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells.
Inactivation of bel renders cells less sensitive to several anti-proliferative signals inducing G1 arrest.
Title: Mutation of the DEAD-box helicase belle downregulates the cyclin-dependent kinase inhibitor Dacapo.
Zn72D and Bel work together to control maleless splicing and protein levels
Title: The zinc finger protein Zn72D and DEAD box helicase Belle interact and control maleless mRNA and protein levels.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamete generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ecdysone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: belle

Names: CG9748-PA; CG9748-PB; bel-PA; bel-PB; capon; lethal (3) L4740; lethal (3) S047110

NP_001262379.1

EC 3.6.4.13

NP_536783.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8654975..8660761 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275450.1 → NP_001262379.1 belle, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262379.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGU4, M9W6J0

Conserved Domains (3) summary

smart00487
Location:315 → 529

DEXDc; DEAD-like helicases superfamily

cd00268
Location:297 → 516

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:538 → 654

Helicase_C; Helicase conserved C-terminal domain
NM_080522.4 → NP_536783.1 belle, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536783.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SXI8, Q9VHP0

UniProtKB/TrEMBL

A0A0H4XWW0, M9W6J0

Related

FBpp0081374

Conserved Domains (2) summary

cd18787
Location:527 → 663

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cd18051
Location:275 → 522

DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3