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Faa Fumarylacetoacetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45577, updated on 9-Dec-2024

Summary

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Official Symbol
Faaprovided by FlyBase
Official Full Name
Fumarylacetoacetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0016013
Locus tag
Dmel_CG14993
See related
AllianceGenome:FB:FBgn0016013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14993; dfaa; Dmel\CG14993; l(3)64Al; l(3)SH11
Summary
Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Is expressed in embryonic Malpighian tubule; embryonic dorsal epidermis; and embryonic pars intercerebralis. Human ortholog(s) of this gene implicated in tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Faa in Genome Data Viewer
Location:
64A5-64A5; 3-10 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4072032..4073954, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4072032..4073954, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene disembodied Neighboring gene wishful thinking Neighboring gene uncharacterized protein Neighboring gene Glutamic acid decarboxylase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Presynaptic glutamic acid decarboxylase is required for induction of the postsynaptic receptor field at a glutamatergic synapse. Featherstone DE, et al. Neuron, 2000 Jul. PMID 10939332
  2. wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Aberle H, et al. Neuron, 2002 Feb 14. PMID 11856529
  3. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. Chávez VM, et al. Development, 2000 Oct. PMID 10976044
  4. Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila. Cheng J, et al. Int J Mol Sci, 2023 Oct 25. PMID 37958569, Free PMC Article
  5. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fumarylacetoacetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fumarylacetoacetase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in homogentisate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tyrosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fumarylacetoacetase
Names
CG14993-PA
Faa-PA
NP_524830.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4072032..4073954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080091.4 → NP_524830.2  fumarylacetoacetase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524830.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0P3, Q9VZI8
    Related
    FBpp0073134
    Conserved Domains (3) summary
    PLN02856
    Location:1 → 414
    PLN02856; fumarylacetoacetase
    pfam01557
    Location:121 → 409
    FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family
    pfam09298
    Location:17 → 115
    FAA_hydrolase_N; Fumarylacetoacetase N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZI8 Q9VZI8

Gene LinkOut

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