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can cannonball [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45432, updated on 9-Dec-2024

Summary

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Official Symbol
canprovided by FlyBase
Official Full Name
cannonballprovided by FlyBase
Primary source
FLYBASE:FBgn0011569
Locus tag
Dmel_CG6577
See related
AllianceGenome:FB:FBgn0011569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Can; CG6577; Dmel\CG6577; dmTAF5b; dTAF5L; dTAF[[II]]80; TAF5; taf5L; Taf5L; TAF5L; WSB-1; WSB1
Summary
Involved in male meiosis I; regulation of gene expression; and spermatid development. Located in male germ cell nucleus and nucleolus. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See can in Genome Data Viewer
Location:
67D12-67D12; 3-32 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10263909..10267111, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10257009..10260211, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44539 Neighboring gene long non-coding RNA:CR44540 Neighboring gene long non-coding RNA:CR45242 Neighboring gene Odorant receptor 67d

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription factor IID--not so basal after all. Verrijzer CP. Science, 2001 Sep 14. PMID 11557865
  2. Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn. Hwa JJ, et al. Mech Dev, 2002 Aug. PMID 12128227
  3. The piRNA pathway is developmentally regulated during spermatogenesis in Drosophila. Quénerch'du E, et al. RNA, 2016 Jul. PMID 27208314, Free PMC Article
  4. Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location. Yu J, et al. Dev Biol, 2002 Apr 15. PMID 11944949
  5. Approaches to defining the ancestral eukaryotic protein complexome. Ceulemans H, et al. Bioessays, 2006 Mar. PMID 16479579

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dj encodes proteins of the spermatid nucleus and the flagellum and is regulated at the transcriptional level by can.
    Title: In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elements.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
cannonball
Names
CG6577-PA
can-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10263909..10267111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080088.2 → NP_524827.1  cannonball [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT91
    Related
    FBpp0076028
    Conserved Domains (4) summary
    cd08044
    Location:320 → 453
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    COG2319
    Location:503 → 829
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:619 → 823
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:629 → 666
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VT91 Q9VT91

Gene LinkOut

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