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pk - prickle

Predicted to enable zinc ion binding activity. Involved in several processes, including establishment of planar polarity; establishment or maintenance of microtubule cytoskeleton polarity; and positive regulation of cell projection organization. Located in plasma membrane. Is expressed in several structures, including appendage; embryonic/larval epidermis; embryonic/larval optic lobe; epithelial furrow; and imaginal disc. Used to study epilepsy. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to several human genes including PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa