na narrow abdomen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: naprovided by FlyBase
Official Full Name: narrow abdomenprovided by FlyBase
Primary source: FLYBASE:FBgn0002917
Locus tag: Dmel_CG1517
See related: AllianceGenome:FB:FBgn0002917
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha1U; CG1517; Dma1U; Dmalpha1U; Dmel\CG1517; har; har 38; har 85; har38; har85; harA; Na; NA; NALCN
Summary: Enables monoatomic ion channel activity. Involved in several processes, including locomotor rhythm; response to anesthetic; and sensory perception of touch. Located in axon terminus and neuronal cell body. Part of cation channel complex. Is expressed in adult head; adult optic lobe; ellipsoid body; spermatozoon; and supraesophageal ganglion. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Orthologous to human NALCN (sodium leak channel, non-selective). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (14266367..14277416)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (14160400..14171449)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic transmission, cholinergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to anesthetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
part_of cation channel complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info