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clbC colibactin polyketide synthase ClbC [ Citrobacter koseri ATCC BAA-895 ]

Gene ID: 45135052, updated on 3-Dec-2024

Summary

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Gene symbol
clbC
Gene description
colibactin polyketide synthase ClbC
Locus tag
CKO_RS03755
Gene type
protein coding
Organism
Citrobacter koseri ATCC BAA-895 (strain: ATCC BAA-895)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Citrobacter
Old locus tag
CKO_00860
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Genomic context

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Sequence:
NC_009792.1 (829173..831773)

NC_009792.1Genomic Context describing neighboring genes Neighboring gene colibactin biosynthesis LuxR family transcriptional regulator ClbR Neighboring gene colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB Neighboring gene colibactin biosynthesis dehydrogenase ClbD Neighboring gene colibactin biosynthesis aminomalonyl-acyl carrier protein ClbE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009792.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways. Engel P, et al. Appl Environ Microbiol, 2015 Feb. PMID 25527542, Free PMC Article
  2. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Nougayrède JP, et al. Science, 2006 Aug 11. PMID 16902142

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
colibactin polyketide synthase ClbC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009792.1 Reference assembly

    Range
    829173..831773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_001297908.1 MULTISPECIES: colibactin polyketide synthase ClbC [Enterobacterales]

    See identical proteins and their annotated locations for WP_001297908.1

    UniProtKB/TrEMBL
    A0A0J2FZE1, A0A1C1IWY9, A0A454A565, A0AAQ0VDA3, A0AAW9DXQ1, Q0P7J3, S1P918
    Conserved Domains (2) summary
    cd00833
    Location:10 → 431
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00550
    Location:787 → 846
    PP-binding; Phosphopantetheine attachment site

Gene LinkOut

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