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cradd CASP2 and RIPK1 domain containing adaptor with death domain [ Danio rerio (zebrafish) ]

Gene ID: 450046, updated on 2-Nov-2024

Summary

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Official Symbol
craddprovided by ZNC
Official Full Name
CASP2 and RIPK1 domain containing adaptor with death domainprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-168
See related
Ensembl:ENSDARG00000028192 AllianceGenome:ZFIN:ZDB-GENE-041010-168
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:101717
Summary
Predicted to enable death domain binding activity and protease binding activity. Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cradd in Genome Data Viewer
Location:
chromosome: 4
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18383080..18416759, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18394104..18427783, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene plexin-C1-like Neighboring gene uncharacterized LOC108183547 Neighboring gene non-SMC condensin II complex, subunit H2 Neighboring gene suppressor of cytokine signaling 2 Neighboring gene synthesis of cytochrome C oxidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tissue factor pathway inhibitor-2: a novel gene involved in zebrafish central nervous system development. Zhang Y, et al. Dev Biol, 2013 Sep 1. PMID 23796905
  2. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables death domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
death domain-containing protein CRADD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006066.1 → NP_001006066.1  death domain-containing protein CRADD

    See identical proteins and their annotated locations for NP_001006066.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083256
    UniProtKB/TrEMBL
    B2GRV1, Q5RGW2, Q5XJP2
    Related
    ENSDARP00000038654.5, ENSDART00000033717.6
    Conserved Domains (2) summary
    cd08319
    Location:117 → 199
    Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
    cd08327
    Location:1 → 91
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    18383080..18416759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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