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si:ch73-40i7.5 si:ch73-40i7.5 [ Danio rerio (zebrafish) ]

Gene ID: 449850, updated on 9-Dec-2024

Summary

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Official Symbol
si:ch73-40i7.5provided by ZNC
Official Full Name
si:ch73-40i7.5provided by ZNC
Primary source
ZFIN:ZDB-GENE-041008-110
See related
Ensembl:ENSDARG00000090675 AllianceGenome:ZFIN:ZDB-GENE-041008-110
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi35e07; im:7137597; wu:fi35e07
Summary
Predicted to enable amyloid-beta binding activity. Predicted to be involved in chemical synaptic transmission. Predicted to be active in cytoplasm; dendritic spine; and plasma membrane. Orthologous to human APBA3 (amyloid beta precursor protein binding family A member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See si:ch73-40i7.5 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (5565169..5583193)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (5618868..5636887)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch73-40i7.2 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 7 Neighboring gene R3H domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
amyloid-beta A4 precursor protein-binding family A member 3; uncharacterized protein LOC449850

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    5565169..5583193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224265.1 → XP_068080366.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

  2. XM_003199417.5 → XP_003199465.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M1RNN4, E7FED4
    Related
    ENSDARP00000099375.2, ENSDART00000112590.4
    Conserved Domains (2) summary
    cd00992
    Location:649 → 723
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:371 → 527
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
Nucleotide Protein Strain
Heading Accession and Version

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